To compare the effect of general anesthesia and subarachnoid block on venous distention reflex
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Change in blood pressure by 10 mm Hg
研究概览
简要总结
This is a non randomised comparitive study to find the effect of general anesthesia and subarachnoid block on venous distention reflex. Increase in blood pressure following venousdistention through sympathetic activation (Limb venous distension reflex) has been demonstrated in literature. After including patients according to inclusion and exclusion criteria, peripheral venous access and an arterial line areobtained and tourniquet is placed. The base linevenous pressure is noted. The tourniquet pressure is kept at 50 mmHg and saline is infused at rate of 30 ml/min for 4 min to distend the veins. The blood pressures are then noted. We postulate that venous distention reflex will not be altered under anesthesia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Not Applicable
- 盲法
- Participant, Investigator, Outcome Assessor and Date-entry Operator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •1.Diabetic patients 2.Hypertensives not on betablockers 3.CKD (not on dialysis) 4.ASA I patients undergoing surgery with Invasive Blood Pressure.
排除标准
- •1.Refusal of consent 2.Patients on drugs affecting autonomic nervous system 3.Vascular surgery.
结局指标
主要结局
Change in blood pressure by 10 mm Hg
时间窗: 4 minutes after infusion of saline under tourniquet inflation | 1. before anesthesia | 2. after anesthesia
次要结局
未报告次要终点