The Importance of Amino Acid Availability in Modulating the Muscle Anabolic Response to β2-adrenergic Stimulation.
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 36
- 试验地点
- 1
- 主要终点
- Skeletal muscle hypertrophy
研究概览
简要总结
The purpose of the project is to investigate the effect of amino acid availability on the muscle anabolic response to beta2-adrenergic stimulation in young healthy men and women.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 18-40
- •Physically active >5 hours a week
- •Maximum oxygen uptake classified as high or very high
排除标准
- •Active smoker currently or within the past 5 years
- •Regular intake of medication deemed by the responsible study physician to affect the test parameters (hormonal contraception is accepted for women)
- •Chronic or acute illness deemed by the responsible study physician to affect the test parameters
- •Deviation from the study protocol
- •Lean mass index >21 kg/m²
- •Pregnancy
- •Blood donation during the past 3 months
研究组 & 干预措施
Salmeterol + amino acid availability
The participants will be administered salmeterol from an inhaler device and amino acid availability (protein powder in a shaker) daily during a 6-week intervention.
干预措施: Salmeterol + amino acid availability (Drug)
Placebo + placebo
The participants will be administered placebo from an inhaler device. Furthermore they will be administered placebo (carbo fuel in a shaker) daily during a 6-week intervention.
干预措施: Placebo + placebo (Drug)
结局指标
主要结局
Skeletal muscle hypertrophy
时间窗: Through study completion, an average on 7 weeks
Muscle hypertrophy measured using Dual-energy X-ray Absorptiometry (DXA).
次要结局
- Quadriceps strength(Through study completion, an average on 7 weeks)
- Power output during sprint testing(Through study completion, an average on 7 weeks)
- Power output during time trial(Through study completion, an average on 7 weeks)
研究者
Morten Hostrup, PhD
Associate Professor
University of Copenhagen