Evaluating classical etiopathogenesis of Shvitra (Vitiligo) in current era in relation to Prakriti and Biochemical Markers-A case control study.

InAyurveda skin diseases are considered in the umbrella of kustha. Kustha is the termgiven to the group of symptoms accrued in the skin disease. Kustha which arefurther divided into maha and kshudra kustha, however SHVITRA has notbeen counted among various type of kustha in brihatrayi later on this has beenincluded under type of kustha but difference between SHVITRA and kusthais based on non-secretary,non-infectious, involvement of twaka ,peculiarity ofnidana, asadhya lakshana and chronicity. According to Modern dermatology, SHVITRAcan be incorporated into broad heading of leukoderma/vitiligo of unknown aetiologyeven today. On the face is ranked 17th by W.H.O. in world’s mostdisabling (mentally and socially) disease. In Ayurveda no separatedescription on aetiology is available of SHVITRA, but general aetiologyof kustha is to be taken under consideration to understand the etiopathogenesisof the disease. Main reason behind SHVITRA based on Ayurvedapathophysiology is consider due to indulgence of a person in the injudiciousdietetics, habit, virudha ahara vihara. It has been widely accepted by all the authors.Acharya charaka has listed the SHVITRA under Rakta pradoshaja vikaar**.** According to Asthang Hridya and Asthang Sangrahaincreased intake of kaphaj aahar-vihaar by mother during pregnancy may lead toappearance of SHVITRA. In Pauranik kala Manusmriti hascontraindicated ten families including SHVITRA affected family for marriage,above all factor could be genetic predisposing of SHVITRA (M.N.3)**.**So,from various Ayurvedic literature Rakta dusti and virudha ahara- vihara, maternalhabit of food and life style (during pregnancy) can consider as a causativefactor of SHVITRA, but definite cause and aetiology is still unknown. From modern point of view, vitiligo can betreated by many numbers of ways like therapy and surgery but exact aetiology isstill unknown. EvenVRF (vitiligo research foundation, America) is still working on exact aetiologyof vitiligo. InAyurveda we have to certainly need to generate a sufficient evidence base forpathogenesis of SHVITRA with help of modern science,technologies,andexperimental rigours in order for it to gain under global acceptance.Indentificationof biochemical marker, could lead to new approach to the prevention andevidence based preventive protocol for  SHVITRA,relation of prakriti assessment also undertaken to consolidate the evidence ofsuch association which exits between Prakriti, Rakta dusti, ahara vihara and manasanidana of *SHVITRA.*The Constituent of prakriti present a set ofmetabolic tendencies, which may be contribute as a trigger factor when combinedwith factor like environmental, diet, lifestyle in development of SHVITRA.