Omentin-1 Level in Psoriatic Patients Treated With Narrowband Ultraviolet B Phototherapy Versus Acitretin
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Decrease Omentin-1 serum level in both groups treated with NB-UVB and Acitretin
研究概览
简要总结
Studying the effects of Narrowband Ultraviolet B versus acitretin on psoriatic patients
详细描述
Compare the effects of Narrowband Ultraviolet B versus acitretin on serum Omentin-1 level in psoriatic patients as case control study by dividing patients into 3 groups: group 1 include patients receive Narrowband Ultraviolet B, group II includes patients receive acitretin (0.5-1 mg/day) and control group. The duration of this study about 3 months after receving those interventions.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients of both sexes with psoriasis vulgaris.
排除标准
- •• Patients with history of malignancies, renal and liver diseases.
- •Patients received NB-UVB phototherapy in the last 6 months.
- •Patients treated with methotrexate or biologic agents and any systemic treatment of psoriasis.
研究组 & 干预措施
NB-UVB group
Patients who receive Narrowband ultraviolet B phototherapy
干预措施: Narrowband Ultraviolet B (Radiation)
Acitretin group
Patients who receive acitretin
干预措施: Acitretin (Drug)
结局指标
主要结局
Decrease Omentin-1 serum level in both groups treated with NB-UVB and Acitretin
时间窗: 3 months
This outcome indicates potential role of Omentin-1 in psoriasis pathogenesis and its involvement in pathogenesis of obesity and related diseases as metabolic syndrome. So it will be concluded that high levels of this protein could be marker against obesity and related disorders including psoriasis. Omentin-1 can be valuable marker for psoriasis severity detected by its correlation with psoriasis area severity index (PASI) score and for evaluating the therapeutic outcomes
次要结局
- Decrease PASI score in psoriatic patients(3 months)
研究者
Mahmoud Ahmed Ali Ahmed
Assistant lecturer
Aswan University Hospital