NCT05739110已完成不适用
Optimizing Hepatocellular Carcinoma Disease Staging Systems by Incorporating Tumor Micronecrosis: A Multi-institutional Retrospective Study
Zhejiang University1 个研究点 分布在 1 个国家目标入组 1,100 人开始时间: 2022年7月15日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 1,100
- 试验地点
- 1
- 主要终点
- Overall survival
研究概览
简要总结
Tumor micronecrosis is a pathological feature that reflects malignant biological behavior in hepatocellular carcinoma (HCC). This study aimed to evaluate the prognostic significance of tumor micronecrosis based on the current BCLC and TNM staging systems, and futher improve the performance of the staging models by establishing modified new staging models including tumor micronecrosis.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •primary and histologically confirmed HCCs
- •patients who underwent curative liver resection
排除标准
- •simultaneous presence of other tumors
- •patients who had received preoperative antitumor therapies
- •no available surgical specimens for evaluating micronecrosis status
- •gross tumor necrosis and Nscore = 3
结局指标
主要结局
Overall survival
时间窗: from date after liver resection until death or last follow-up, whichever came first, assessed up to 72 months
the number of months from the date of surgery to the date of the last follow-up visit or time of death.
次要结局
- Disease-free survival(from date after liver resection until recurrence or last follow-up, whichever came first, assessed up to 72 months)
研究者
TingBo Liang
Director
Zhejiang University
研究点 (1)
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