A randomized, prospective, pilot study comparing the efficacy of Selective Laser Trabeculoplasty versus Brimonidine tartrate 0.2%/Timolol maleate 0.5% (Combigan, Allergan Inc.) in lowering intraocular pressure as adjunct therapy in Primary Open Angle Glaucoma.

niversity of Pikeville Kentucky College of Optometry0 个研究点目标入组 23 人开始时间: 2018年12月14日最近更新: 2021年10月11日

适应症

试验速览

2019 Preprint results in https://doi.org/10.21203/rs.2.473/v1 (added 28/09/2021) 2021 Results article in http://dx.doi.org/10.24966/OCR-8887/100075 (added 28/09/2021)

•1. Uncontrolled primary open angle glaucoma
•2. Open angle on gonioscopy
•3. Aged 25 to 90 years
•4. Currently taking a prostaglandin analog, but IOP not controlled with monotherapy

•1. Best corrected visual acuity worse than 20/40 in the study eye (meaning 20/50 or worse)
•2. Hx of angle closure or an occludable angle on gonioscopy
•3. Untreated IOP less than or equal to 21 mmHg
•4. Patients who have used a second IOP lowering medication in the past 2 months
•5. Angle recession on gonioscopy
•6. Pseudoexfoliation glaucoma
•7. Pigment dispersion glaucoma
•8. Prior incisional glaucoma surgery
•9. Prior Microinvasive Glaucoma Surgery (MIGS, istent, Endocyclophotocoagulation)
•10. Previous SLT or Argon Laser Trabeculoplasty (ALT)
•11. Previous Laser Peripheral Iridotomy (LPI)
•12. Previous refractive surgery
•13. Inflammatory eye disease
•14. Contraindication to any of the topical medicines including asthma, chronic obstruction pulmonary disease, bradycardia, or a hypersensitivity reaction.
•15. A change in dosage, or addition of, a systemic medication that could effect IOP during the study
•16. Women who are pregnant or who intend to become pregnant in the next 4 months (as verbally asked during the medical history and consenting process, no formal pregnancy test will be administered for this study)
•17. Patients with significant dementia who are not able to fully comprehend the informed consent

发起方

niversity of Pikeville Kentucky College of Optometry