NCT01231360Unknown不适用
The Effect of Exercise Training on Skeletal Muscle Metabolism in Peripheral Artery Disease
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 75
- 试验地点
- 2
- 主要终点
- Expression of genes regulating skeletal muscle metabolism
研究概览
简要总结
Specific Aim 1: To test the hypothesis that subjects with PAD and intermittent claudication have altered expression of genes that regulate skeletal muscle metabolism.
Specific Aim 2: To test the hypothesis that exercise training improves calf skeletal muscle insulin resistance and genes that regulate skeletal muscle metabolic function in PAD patients with intermittent claudication.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 40 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •claudication symptoms
- •ABI ≤ 0.9 in the symptomatic leg
排除标准
- •impaired fasting glucose
- •peripheral vascular intervention within the prior six months
- •recent unstable angina
- •myocardial infarction or stroke within the prior six months
- •changes to their HMG-CoA reductase inhibitor (statin)within the past three months
- •changes to pentoxifylline and/or cilostazol regimen within the past three months or anticipated to be necessary during the study
- •are on Coumadin
- •exercise limitations for reasons other than intermittent claudication (such as congestive heart failure, angina, chronic lung disease, or other disorders affecting the limb such as arthritis or neuropathy)
- •rest pain or ulcers due to critical limb ischemia
- •lower extremity amputation
结局指标
主要结局
Expression of genes regulating skeletal muscle metabolism
时间窗: 3 months
次要结局
- Additional measures include skeletal muscle glucose uptake, measures of functional capacity, leg blood flow, and quality of life.(3 months)
研究者
Reena Pande, MD
Instructor, Harvard Medical School
Brigham and Women's Hospital
研究点 (2)
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