Point of Care Testing of Cholinesterase Activity During Burn- and Polytrauma
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 85
- 试验地点
- 1
- 主要终点
- Early diagnosis of the systemic inflammation by using the serum cholinesterase activity measurement
研究概览
简要总结
Goal of this study is to measure serum cholinesterase activity in patients with traumatic and/or burns injury admitted to the emergency room by using point-of- care-test system (POCT). Serum cholinesterase activity, measured using POCT system, might play an important role in the early diagnosis and prediction of patient outcome in trauma-induced systemic inflammation.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •signed written consent
- •18 years and older
- •severe trauma (ISS > 15)
- •burns injury (
- •degree more than 15% body surface or 3 degree more than 10% body surface)
排除标准
- •not fulfilling the inclusion criteria
- •failure to adhere
结局指标
主要结局
Early diagnosis of the systemic inflammation by using the serum cholinesterase activity measurement
时间窗: after completed patient recruitment, 1 year
By using Point-of-care measurement of serum cholinesterase activity (U/l) and by observing a change in the enzyme activity over time (reduction of serum cholinesterase activity within the first 6 hours after traumatic injury) would allow an additional tool in early diagnosis and treatment of systemic inflammation.
次要结局
- correlation of the cholinesterase activity and the trauma/disease severity scores(after completed patient recruitment, 1 year)
研究者
Aleksandar Zivkovic
Dr. med. Aleksandar Zivkovic
University Hospital Heidelberg