Randomized Controlled Trial of the Effect of Continuous Positive Airway Pressure on Adipocyte Fatty Acid Binding Protein and Other Metabolic Markers in Obstructive Sleep Apnea
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 90
- 试验地点
- 2
- 主要终点
- adipocyte fatty acid binding protein
研究概览
简要总结
Adipocyte fatty acid binding protein (A-FABP) is a member of the FABP super family, is abundant in adipocytes and macrophages. Regulatory functions of A-FABP in lipid and glucose metabolism have been described, and it is suggested to play an important role in the pathogenesis of metabolic syndrome.We hypothesize that obstructive sleep apnea (OSA) may upregulate A-FABP production and thus causally contribute to metabolic dysfunction. Our group has recently demonstrated that A-FABP, expressed and secreted from adipocytes, is present in the blood stream .The levels of A-FABP correlated with various metabolic variates in the metabolic syndrome. Furthermore, we have obtained novel data in men with a range of sleep disordered breathing showed that the duration of oxygen desaturation correlated with circulating levels of A-FABP, independent of age and waist/body mass index. The current proposal aims to pursue this finding and further explore the role of A-FABP in the association of OSA and metabolic dysfunction.
详细描述
We hypothesize that there are changes in circulating A-FABP level which can be mitigated by effective treatment of OSA.
The aim is to investigate the effect of CPAP treatment of OSA on circulating A-FABP, and other metabolic biomarkers and cardiovascular parameters
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Subjects between 18 - 65 years old
- •Able to understand and give informed written consent
排除标准
- •BMI > 35 kg/m2, and features of obesity hypoventilation syndrome
- •known diabetes mellitus or hyperlipidemia on treatment
- •known cardiovascular disease except hypertension stable on treatment
- •unstable medical illness
- •need for starting treatment for OSA or other medical conditions immediately
研究组 & 干预措施
continuous positive airway pressure
using continuous positive airway pressure (CPAP) device during sleep, for the study period (4 weeks)
干预措施: continuous positive airway pressure (Device)
control
observation for the study period (4 weeks, no CPAP)
结局指标
主要结局
adipocyte fatty acid binding protein
时间窗: changes over 4 weeks of CPAP treatment
blood assay
次要结局
- Lipids and lipoprotein(changes over 4 weeks of CPAP treatment)
- Insulin and glucose(changes over 4 weeks of CPAP treatment)
- blood Markers of oxidative stress and fat metabolism(changes over 4 weeks of CPAP treatment)
- blood inflammatory markers(changes over 4 weeks of CPAP treatment)
- Epworth sleepiness scale(changes over 4 weeks of CPAP treatment)
- blood pressure(changes over 4 weeks of CPAP treatment)