CALIFORNIA trial
Recruiting
- Conditions
- ecrotising enterocolitisNear Infrared Spectroscopy (NIRS)Faecal microbiotaBiomarkersGut wall integrityBile acids
- Registration Number
- NL-OMON22270
- Lead Sponsor
- niversity Medical Center Groningen
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
All children admitted to the neonatology department, which are
- born at a gestational age of <30 weeks or
Exclusion Criteria
Other abdominal diseases, e.g. abdominal wall defects or congenital intestinal atresias
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The development of necrotising enterocolitis as determined by an independent paediatric radiologist (pneumatosis intestinalis on abdominal x-ray) or by surgeon during surgery
- Secondary Outcome Measures
Name Time Method rinary i-FABP/creatinin ratio, urinary 8-OHdG/creatinine ratio, urinary F2-IsoP/creatinin ratio, faecal Calprotectin and faecal bile acids, gene-expression (ao.TLR-4) on shedded enterocytes in the faeces, GLP1/2 in plasma, bile-acids in plasma, and regional tissue oxygenation measured by abdominal/cerebral NIRS.