Investigating the Interaction of Apelin and Angiotensin II Peripheral Resistance Vessels in Vivo in Man
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- Change in apelin mediated forearm blood flow
研究概览
简要总结
The apelin-APJ system is a relatively new discovery. It has generated interest in part due to it's apparent ability to counteract the renin-angiotensin system, which is frequently overactive in many cardiovascular disease.
Angiotensin has a powerful ability to cause blood vessels constrict and reduces their diameter. One of the actions of apelin is to cause blood vessels to relax and the investigators specifically wish test the hypothesis that apelin will cause blood vessels constricted by angiotensin II to relax.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •> 18 years old
排除标准
- •Lack of informed consent
- •Age < 18 years,
- •Current involvement in other research studies,
- •Systolic blood pressure >190 mmHg or <100 mmHg
- •Malignant arrhythmias
- •Renal or hepatic failure
- •Haemodynamically significant aortic stenosis
- •Severe or significant co morbidity
- •Women of childbearing potential.
- •Any regular medication
- •Previous history of any cardiovascular disease
研究组 & 干预措施
Angiotensin II infusion
Using forearm venous occlusion plethysmography angiotensin II will be infused to cause reduction in forearm blood flow. Infusion of apelin and sodium nitroprusside will given and vasodilatation will be assessed. Blood samples for the infused arm and contra-lateral arm will be taken at regular time points to assess local and systemic changes in relevant hormones.
干预措施: Apelin infusion (Drug)
Angiotensin II infusion
Using forearm venous occlusion plethysmography angiotensin II will be infused to cause reduction in forearm blood flow. Infusion of apelin and sodium nitroprusside will given and vasodilatation will be assessed. Blood samples for the infused arm and contra-lateral arm will be taken at regular time points to assess local and systemic changes in relevant hormones.
干预措施: Sodium nitroprusside infusion (Drug)
Noradrenaline
Using forearm venous occlusion plethysmography noradrenaline will be infused to cause reduction in forearm blood flow. Infusion of apelin and sodium nitroprusside will given and vasodilatation will be assessed. Blood samples for the infused arm and contra-lateral arm will be taken at regular time points to assess local and systemic changes in relevant hormones.
干预措施: Apelin infusion (Drug)
Noradrenaline
Using forearm venous occlusion plethysmography noradrenaline will be infused to cause reduction in forearm blood flow. Infusion of apelin and sodium nitroprusside will given and vasodilatation will be assessed. Blood samples for the infused arm and contra-lateral arm will be taken at regular time points to assess local and systemic changes in relevant hormones.
干预措施: Sodium nitroprusside infusion (Drug)
结局指标
主要结局
Change in apelin mediated forearm blood flow
时间窗: 12 months
次要结局
- Change in local and systemic plasma apelin concentration in response angiotensin II infusion(12 months)