Multimodal MRI Study of Accumbofrontal Tract in Anorexia Nervosa and Obessional Compulsive Disorder : Search for Structural and Functional Changes Between Orbito-frontal Cortex and Accumbens Nucleus Subdivisions
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Fractional Anisotropy (probabilistic tractography)
研究概览
简要总结
Restrictive anorexia nervosa and TOCs are psychiatric diseases which shares a common pathophysiological substrate We hypothesize that anorexia patients and patients with OCD have structural and functional changes in the accumbofrontal tract. The main objective of this study will be to compare the structure and the connectivity of this tract in MRI with diffusion sequences (DTI tractography) and resting-state, in 3 distinct populations of anorexic patients, patients with OCD and healthy patients. The role of the accumbo-frontal tract in the cortico-striato-hypothalamo-cortical circuit seems to be established. DTI tractography will allow the measurement of functional anisotropy (FA), a parameter that evaluates the diffusion of water molecules along the white matter fibers, and therefore the potential alteration of the studied tract. Resting state sequences will allow to estimate the BOLD signal and the functionality of the tract.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Female patients
- •Age between 18 and 65 years
- •Subjects free to give their written consent
- •For anorexia nervosa :
- •Patients meeting the diagnostic criteria for anorexia nervosa according to DSM5 (American Psychiatric Association): low weight (<85% of expected weight for age and height), fear of gaining weight or becoming fat, distortion of body image, and amenorrhea for more than 3 months
- •Treatment with at least one antidepressant and one anxiolytic
- •Patients meeting the diagnostic criteria of OCDs according to DSM5 (American Psychiatric Association) : presence of obsessions and / or compulsions, resulting in clinically significant suffering (loss of at least one hour per day) or impairment at the social, occupational level or in another important area of life. These symptoms are not due to the physiological effects of a substance or a general medical condition and cannot be better explained by the symptoms of another psychiatric disorder.
- •Patients with homogeneous OCD in obsession and compulsion.
- •Normal weight compared to expected weight for age and height
- •Treatment with at least one antidepressant and one anxiolytic
- •ForHealthy volunteer
- •Normal weight compared to expected weight for age and height
排除标准
- •Age <18 years or> 65 years
- •Pregnancy
- •Absence of free and informed consent signature
- •Current processing by rTMS
- •Somatic intercurrent pathologies: neurological, cardiological, pneumological, renal, hepatic, endocrine, metabolic disorders ...
- •Mental retardation (WAIS-IV QI <70)
- •Primary Amenorrhea
- •Absolute contraindication or relative to the realization of a magnetic resonance imaging without injection of contrast medium
- •Old or intercurrent psychotic pathology
结局指标
主要结局
Fractional Anisotropy (probabilistic tractography)
时间窗: 20 minutes
Evaluate the mean functional anisotropy value for fiber bundles connecting the orbito-frontal cortex and the nucleus accumbens
次要结局
- BOLD Signal (resting state)(20 minutes)