Does Beta-alanine Supplementation Augment the Skeletal Muscle Adaptive Response to 8 Weeks of High-intensity Interval Training
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 26
- 试验地点
- 2
- 主要终点
- Change from baseline work done on a cycle ergometer in a cycling capacity test at 110%VO2max following a period of 4 weeks of beta-alanine supplementation and then 8 weeks of beta-alanine supplementation and high intensity interval training
研究概览
简要总结
The present study will seek to quantify whether a period of HIIT alongside β-alanine supplementation will improve the adaptation to training, and therefore performance, more than a period of HIIT alone.
详细描述
Whilst high-intensity interval training (HIIT) is a powerful stimulus to increase endurance exercise performance, there are potential nutritional interventions that can be put in place to further increase performance gains.
Energy for the contraction of muscles is created in the mitochondria. HIIT can improve the function of mitochondria, therefore improving performance.
Β-alanine is a commonly used supplement that can improve exercise performance by increasing the amount of carnosine in muscle. Carnosine has many functions that may help improve exercise capacity.
The present study will seek to quantify whether a period of HIIT alongside β-alanine supplementation will improve the adaptation to training, and therefore performance, more than a period of HIIT alone.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
盲法说明
Doubly-blinded & randomised using an online randomisation website.
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Moderately trained (vo2max: 50 - 60 ml/kg/min).
- •Females must be taking an oral contraceptive, or using a contraceptive implant.
排除标准
- •A recent history of musculoskeletal injury
- •Diagnosed cardiovascular or metabolic disease
- •Regular use of beta-alanine supplements
结局指标
主要结局
Change from baseline work done on a cycle ergometer in a cycling capacity test at 110%VO2max following a period of 4 weeks of beta-alanine supplementation and then 8 weeks of beta-alanine supplementation and high intensity interval training
时间窗: At weeks 0, 4 and 12 of study.
Subjects will have previously performed an incremental test to exhaustion (VO2max test). A work-load that corresponds to 110 % of the peak power output (Wmax) will be calculated, and participants will be asked to cycle at this power output until volitional exhaustion. This test will be preceded but a bout of 90-minute cycling at 65%VO2max. Tests will be performed on a Lode Excalibur Sport, and software linked to the bike will record data.
次要结局
- VO2max(At weeks 0, 4, 8 and 12 of study.)
- Muscle carnosine concentration(At weeks 0, 4 and 12 of study.)
- Muscle buffering capacity(At weeks 0, 4 and 12 of study.)
- Heart rate(At weeks 0, 4 and 12 of study, and through whole training period (weeks 8-12))
- Substrate utilisation(At weeks 0, 4 and 12 of study.)
- Muscle gene expression(At weeks 0, 4 and 12 of study.)
- Muscle enzyme (citrate synthase, hexokinase, β-HAD, PFK) activity(At weeks 0, 4 and 12 of study.)
- Muscle metabolites (AMP, ADP, ATP, Pi, IMP, PCr, Cr, lactate, pyruvate, NAD+/NADH, glucose, G6P, citrate)(At weeks 0, 4 and 12 of study.)
- Plasma metabolites (NEFA, glucose, glycerol, lactate)(At weeks 0, 4 and 12 of study.)