Relationship Between Acute Phase Markers and Acute Post-operative Pain in Laparoscopic Cholecystectomy: An Observational Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 54
- 试验地点
- 1
- 主要终点
- Relationship Between Post-operative Pain and white blood cell count in Laparoscopic Cholecystectomy
研究概览
简要总结
Many patients undergoing laparoscopic cholecystectomy are prone to developing acute and chronic post-operative pain.
The aim of the study is to show a possible correlation between pain and acute phase proteins in order to:
- predict the severity of pain;
- select most suitable pain relief therapy for the patient.
详细描述
The day after surgery, some serum markers are determined by a blood sample.
The markers analyzed are:
- Leukocytes;
- C-reactive protein (CRP);
- D-dimer;
- Fibrinogen;
- Neutrophil-to-Lymphocyte Ratio (NLR).
Pain level is assessed using the NRS scale at different times:
- 1st post-operative day;
- 7th post-operative day;
- One month after surgery;
- Three months after surgery;
- Six months after surgery.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patient undergoing laparoscopic cholecystectomy
排除标准
- 未提供
结局指标
主要结局
Relationship Between Post-operative Pain and white blood cell count in Laparoscopic Cholecystectomy
时间窗: one day
The study compares post-operative pain, measured with the NRS scale, with white blood cell count (x 10\^9/L) 24 hours after surgery
Relationship Between Post-operative Pain and C Reactive Protein (CRP) in Laparoscopic Cholecystectomy
时间窗: one day
The study compares post-operative pain, measured with the NRS scale, with CRP (µg/L) levels 24 hours after surgery
Relationship Between Post-operative Pain and D-dimer in Laparoscopic Cholecystectomy
时间窗: one day
The study compares post-operative pain, measured with the NRS scale, with D-dimer (µg/L FEU) levels 24 hours after surgery
Relationship Between Post-operative Pain and Fibrinogen in Laparoscopic Cholecystectomy
时间窗: one day
The study compares post-operative pain, measured with the NRS scale, with fibrinogen (g/L) levels 24 hours after surgery
Relationship Between Post-operative Pain and Neutrophil to Lymphocyte Ratio (NLR) in Laparoscopic Cholecystectomy
时间窗: one day
The study compares post-operative pain, measured with the NRS scale, with Neutrophil to Lymphocyte Ratio (NLR) 24 hours after surgery. NLR results from the ratio between the level of neutrophils and lymphocytes.
次要结局
未报告次要终点
研究者
Augusto Lauro
Associate professor
University of Roma La Sapienza