Is This PJI Really Acute: A Quantitative Sonication Fluid Analysis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 176
- 试验地点
- 1
- 主要终点
- number of bacteria
研究概览
简要总结
This retrospective study is to analyse microbiological cultures from the sonication fluid of the explanted prothesis to detect bacteria in the biofilm on the implant surface and to investigate whether the number of bacteria in the biofilm correlates with the duration of the PJI respectively with the period between symptom onset and date of revision surgery.
详细描述
Implant associated infections in orthopaedics and trauma surgery are a well-known and feared complication. Prosthetic-joint infection (PJI) is caused by a biofilm which is located atop the surface of the implant which as growing with the duration of the PJI. This retrospective study is to analyse microbiological cultures from the sonication fluid of the explanted prothesis to detect bacteria in the biofilm on the implant surface and to investigate whether the number of bacteria in the biofilm correlates with the duration of the PJI respectively with the period between symptom onset and date of revision surgery.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients who underwent a revision surgery of hip, knee and shoulder arthroplasties operated at the university hospital of Basel between 2011 and 2021,
- •patients who had a PJI as a suspected diagnosis and
- •have microbiological cultures from sonication fluid from removed prosthesis.
排除标准
- •patients in the database who
- •have non-bacterial microbiological positive cultures (e.g. fungal infection) and
- •have not received a sonication of the removed prosthesis during the diagnostic process
结局指标
主要结局
number of bacteria
时间窗: one time assessment at baseline
number of bacteria detected during revision surgery will be taken from the sonication fluid and the quantitative analysis of the microbiological samples
duration of the infection
时间窗: one time assessment at baseline
duration of the infection
次要结局
未报告次要终点