Effects of Chronic Dietary Grape Seed Extract Supplementation on Aortic Stiffness and Hemodynamic Responses in Obese/Overweight Males During Submaximal Exercise
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 10
- 试验地点
- 2
- 主要终点
- change in heart rate at rest and during exercise
研究概览
简要总结
It was demonstrated that acute dietary supplementation with GSE reduced arterial blood pressure via reduction in Q in obese individuals. However, no studies have investigated the chronic effects of dietary GSE supplementation on hemodynamic responses during exercise. Given the fact that obesity is associated with an impaired function of eNOS, the effect of chronic dietary GSE supplementation on abnormal blood pressure response to exercise and aortic stiffness (AoS) needs be elucidated. Thus, it is hypothesized that GSE decreases systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), Q, and aortic stiffness at rest and during exercise. This study would determine that this supplementation may be used as a non-pharmacological intervention to prevent incident hypertension and cardiovascular events during exercise via enhanced endothelial function.
详细描述
We investigated whether elevated blood pressure and aortic stiffness (AoS) characterized in obese and overweight males (N=10) are reduced following chronic GSE supplementation during exercise. Systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), heart rate (HR), stroke volume (SV), cardiac output (Q), total vascular conductance (TVC), and AoS to two submaximal cycling exercises (40% and 60% VO2peak) were compared 7 days after ingestion of GSE or placebo (PL) within an one week washout period. Compared with PL, GSE supplementation significantly decreased MAP at rest, 40%, and 60% workloads. AoS was significantly reduced at rest. Q tended to be decreased, but there was no significant difference. GSE had no effect on HR, TVC, and SV. Our study indicates that chronic supplementation with GSE reduces arterial pressure at rest and during exercise primarily via the combined reduction of AoS and Q. Thus, GSE can be a dietary supplement to treat augmented blood pressure responses in obese and overweight males at rest and during exercise.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 29 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Overweight: 25-29.9 kg/m2
- •Obese: > 30 kg/m2
- •Waist circumference: > 90 cm
排除标准
- •Antihypertensive medication
- •Major systemic disease (cancer)
- •Musculoskeletal diseases
- •Cardiovascular diseases or symptoms including chest pain
- •Myocardial infarction
- •Arrhythmias
- •Heart failure
结局指标
主要结局
change in heart rate at rest and during exercise
时间窗: 7 day supplementation
beats per minute
change in stroke volume at rest and during exercise
时间窗: 7 day supplementation
volume per stroke
change in systolic blood pressure at rest and during exercise
时间窗: 7 day supplementation
pressure exerted during contraction
change in cardiac output at rest and during exercise
时间窗: 7 day supplementation
total volume for one minute
change in aortic stiffness at rest
时间窗: 7 day supplementation
Arbitrary unit
change in total vascular conductance at rest and during exercise
时间窗: 7 day supplementation
one reported value (cardiac output/mean arterial pressure)
change in diastolic blood pressure at rest and during exercise
时间窗: 7 day supplementation
pressure exerted during relaxation
次要结局
未报告次要终点