DRKS00011199已完成未知
Metabolism of long-chain polyunsaturated fatty acids and oxylipins
niversität HannoverInstitut für Lebensmittelwissenschaft und Humanernährung0 个研究点目标入组 15 人开始时间: 2016年10月14日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 15
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Non-randomized controlled study
- 盲法
- Open (masking not used)
入排标准
- 年龄范围
- 20 Years 至 40 Years（—）
- 性别
- Male
入选标准
- •Non smoking; omnivores with moderate meat consumption (2x per week) for at least 5 years and low fish consumption (max 1x per week.); written consent of the subjects after detailed oral and written explanation of the course content, requirements and risks; ability and willingness of study participants to follow the instructions of the investigator (compliance with the conditions of the study, taking the test products according to the dosage recommendation, etc.)
排除标准
- •severe chronic diseases (manifest cardiovascular diseases, cancer); insulin-dependent individuals with diabetes mellitus type I and II; serious kidney or liver failure, liver disease, chronic diseases of the gastrointestinal tract (especially the small intestine, liver, pancreas) and conditions after surgery on the gastrointestinal tract; e.g. gastrectomy, celiac disease, enterocolitis, chronic pancreatitis, cholestasis, short bowel syndrome, inflammatory bowel disease; not: appendicitis, gallstone surgery; surgery for stomach stapling, gastric band, gastric balloon; known endocrine and immunological disorders; immediate need of a surgical procedure; simultaneous participation in another clinical trial or participation within the past 30 days; not incapacitated subjects; refusal or withdrawal of consent by the subject; patients taking preparations that contain LC n-3 PUFA, phytosterols, polyglucosamine (chitosan), vitamin E or other lipid-lowering ingredients include; triglyceride (TG) levels = 150 mg / dL (= 1.7 mmol / l); total cholesterol (TC) levels = 200 mg / dL (= 5.2 mmol / l); body mass index (BMI): = 20 kg / m2 and = 27 kg / m2; relative AA content in erythrocyte membranes: 15 ± 3%; Relative EPA / DHA content in erythrocyte membranes (Omega-3 Index): 6 ± 2%; liver enzymes: aspartate aminotransferase (AST) (> 50 U / L), alanine aminotransferase (ALT) (> 50 U / L), ?-glutamyl transferase (GGT) (> 60 U / L); hormonal disorders, such as hyperthyroidism and Cushing's syndrome; regular intake of laxatives; regular intake of nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, aspirin, flurbiprofen, diclofenac; chronic administration of corticosteroids (except inhalative), psychotropic drugs; treatment with lipid lowering agents (e.g., statins, fibrates, Gallensäureaustauscherharze, ezetimibe) in the last three months; diagnosed blood clotting disorders; taking anticoagulants (anticoagulant drugs), as phenprocoumon and platelet aggregation inhibitors, for example, ASS; alcohol, drugs and / or drug abuse
研究者
相似试验
已完成
不适用
Short-term metabolism of long-chain polyunsaturated fatty acids and oxylipinsprevention of civilization diseasesDRKS00012257Institut für Lebensmittelwissenschaft und Humanernährung13
招募中
Unknown
Polyunsaturated fatty acids, trans fatty acids, and colorectal cancer incidence: a systematic review and a meta-analysiscolorectal cancerJPRN-UMIN000049340Ryukoku University
招募中
不适用
Human short chain fatty acid metabolism and microbiotaObesityNL-OMON37878Medisch Universitair Ziekenhuis Maastricht20
已完成
不适用
Metabolic consequences of conjugated linoleic acid supplementation in overweight and obese subjects.E66ObesityDRKS00010462Department of Pediatric Gastroenterology and Metabolic DiseasesPoznan University of Medical Sciences74
已完成
不适用
ong-chain n-3 polyunsaturated fatty acids in relation to gut integrity, growth failure and cognitive development of rural African infantsISRCTN66645725Medical Research Council (UK)150