DRKS00012257已完成未知
Short-term metabolism of long-chain polyunsaturated fatty acids and oxylipins
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 入组人数
- 13
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Non-randomized controlled study
- 盲法
- Open (masking not used)
入排标准
- 年龄范围
- 20 Years 至 40 Years（—）
- 性别
- Male
入选标准
- •Non smoking; omnivores with moderate meat consumption (2x per week) for at least 5 years and low fish consumption (max 1x per week.); written consent of the subjects after detailed oral and written explanation of the course content, requirements and risks; ability and willingness of study participants to follow the instructions of the investigator (compliance with the conditions of the study, taking the test products according to the dosage recommendation, etc.)
排除标准
- •severe chronic diseases (manifest cardiovascular diseases, cancer); insulin-dependent individuals with diabetes mellitus type I and II; serious kidney or liver failure, liver disease, chronic diseases of the gastrointestinal tract (especially the small intestine, liver, pancreas) and conditions after surgery on the gastrointestinal tract; e.g. gastrectomy, celiac disease, enterocolitis, chronic pancreatitis, cholestasis, short bowel syndrome, inflammatory bowel disease; not: appendicitis, gallstone surgery; surgery for stomach stapling, gastric band, gastric balloon; known endocrine and immunological disorders; immediate need of a surgical procedure; simultaneous participation in another clinical trial or participation within the past 30 days; not incapacitated subjects; refusal or withdrawal of consent by the subject; patients taking preparations that contain LC n-3 PUFA, phytosterols, polyglucosamine (chitosan), vitamin E or other lipid-lowering ingredients include; triglyceride (TG) levels = 150 mg / dL (= 1.7 mmol / l); total cholesterol (TC) levels = 200 mg / dL (= 5.2 mmol / l); body mass index (BMI): = 20 kg / m2 and = 27 kg / m2; relative AA content in erythrocyte membranes: 15 ± 3%; Relative EPA / DHA content in erythrocyte membranes (Omega-3 Index): 6 ± 2%; liver enzymes: aspartate aminotransferase (AST) (> 50 U / L), alanine aminotransferase (ALT) (> 50 U / L), ?-glutamyl transferase (GGT) (> 60 U / L); hormonal disorders, such as hyperthyroidism and Cushing's syndrome; regular intake of laxatives; regular intake of nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, aspirin, flurbiprofen, diclofenac; chronic administration of corticosteroids (except inhalative), psychotropic drugs; treatment with lipid lowering agents (e.g., statins, fibrates, Gallensäureaustauscherharze, ezetimibe) in the last three months; diagnosed blood clotting disorders; taking anticoagulants (anticoagulant drugs), as phenprocoumon and platelet aggregation inhibitors, for example, ASS; alcohol, drugs and / or drug abuse
研究者
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