Rehabilitation of Facial Emotion Recognition in Alzheimer's Disease and Study of the Consequences on Gaze Strategy, Behavior Disorders and Family Caregivers' Burden
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 8
- 主要终点
- Facial emotion recognition (FER) performances
研究概览
简要总结
This study aims to evaluate impacts of an emotion recognition rehabilitation program, named Training of Affect Recognition, on social cognition abilities in Alzheimer's disease (AD). In addition, we hypothesis that the effect of this rehabilitation will also evolve gaze strategies, behavioral disorders, and the caregiver's burden.
详细描述
It is commonly admitted that social cognition impairment, like deficit in facial emotion recognition or misinterpretation of others' intentions (Theory of Mind), are associated with social behavior disorders.
This kind of disorders are observed in Fronto-Temporal Dementia, Alzheimer's Dementia (AD) and Parkinson's Disease, with severe deficits in FTD and lighter deficits in AD and PD. One explanation is that patients apply inappropriate visual exploration strategies to decode emotions and intentions of others.
Our study aims to evaluate impacts of an emotion recognition rehabilitation program, named Training of Affect Recognition, on social cognition abilities (facial emotion recognition (FER) and theory of mind (ToM)) in Alzheimer's disease (AD). In addition, we hypothesis that the effect of this rehabilitation will also evolve gaze strategies, behavioral disorders, and the caregiver's burden.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •AD diagnosed according to l'IWG-2 (Dubois & al. 2014) criteria,
- •Mini-Mental State (MMS-E) ≥15
- •Subject accompanied by a family caregiver and whose participation in a cognitive stimulation workshop was recommended in Memory Centre of the RAINIER Centre (Princesses Grace Hospital - Monaco)
- •Written informed consent signed by patient and family caregiver.
排除标准
- •General anaesthesia within 3 months.
- •Ophthalmological or neurological problems preventing a video-oculography examination.
- •Oculomotor disorders such as "fixation disorders" or "ocular tracking disorders".
- •Cognitive disorders of the type: visual agnosia, visuo-spatial disorder, visuo-perceptual disorder or aphasia.
- •History of bipolar disorder or schizophrenia
- •History of alcohol abuse.
结局指标
主要结局
Facial emotion recognition (FER) performances
时间窗: Baseline; Week 6; 1 month post intervention
Change from Baseline and Comparison of FER performance between AD-TAR group and AD-Cognitive Stimulation group. Evaluation criteria: Scores to Ekman Faces task (1976) and time to answer. FER was assessed using pictures from the Ekman Faces task (1976), to test the recognition of the six facial basic emotions and neutral faces. There were four pictures per emotion, for a total of 28. For each picture, participants were asked to select one of the seven labels (anger, disgust, fear, sadness, happiness, surprise and neutral), with a maximum of 8 seconds of response time per picture.
Affective ToM performances
时间窗: Baseline; Week 6; 1 month post intervention
Change from Baseline and Comparison of Affective ToM performance between AD-TAR group and AD-Cognitive Stimulation group. Evaluation criteria: Scores to the " Reading the Mind in the Eyes " test (Baron-Cohen 2001). 36 black-and-white photographs of the eye area of faces. Subjets are asked to choose which word, among four options, best described what the character in the photograph was thinking or feeling. For this task, four scores were obtained: a total score (/36) and three emotional valence sub-scores: positive (/8), neutral (/16) and negative (/12).
次要结局
- Eye gaze strategies during Facial emotion recognition (FER)(Baseline; Week 6; 1 month post intervention)
- The Family caregiver's burden(Baseline; Week 6; 1 month post intervention)
- Behavioral disorders(Baseline; Week 6; 1 month post intervention)
- Global cognitive performance(Baseline; Week 6; 1 month post intervention)