Arginine and nitric oxide (NO) metabolism in sepsis: L-Citrulline enteral supplementation for the normalisation of the Arginine-NO metabolism. - L-citrulline supplementation during sepsis

Algemene Heelkunde0 个研究点目标入组 48 人开始时间: 待定最近更新: 2024年5月6日

适应症

试验速览

暂无简介。

•1. Written informed consent from close relative
•2. Age > 18 years
•3. patient meets the general criteria for severe sepsis or septic shock, diagnosed less than 48 h prior to study inclusion. (according to Levy and Fink et al. Intensive care med 29: 530-538. 2003)
•4. Patient must be relatively hemodynamically stable, defined as stable blood pressure (variation in mean arterial pressure < 15 mm Hg), during 2 h without necessity of increasing the vasopressor dose, inotropic support or rate of fluid administration.
•5. Systemic arterial catheter in place with continous pressure monitoring.
•6. Patients in whom the clinician is prepared to provide full life support during duration of the study.

•1. Shock due to any cause other than sepsis (e.g drug reaction or drug overdose, pulmonary embolus, burn injury etc.)
•2. prolonged or high dose corticosteroid use
•3. chronic pancreatitis
•5. insulin-dependent diabetes mellitus
•6. metastases, haematological malignancies or chemotherapy
•7. patients on dialysis (CVVH or other)
•8. pre-existent renal failure (on dialysis)

发起方

Algemene Heelkunde