Screening for Lung Cancer in Subjects With Family History of Lung Cancer
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 1,520
- 试验地点
- 2
- 主要终点
- The rate of lung cancer detection in subjects with family history of lung cancer
研究概览
简要总结
Lung cancer can be detected via screening of high-risk individuals, i.e current or ex-heavy smokers, with low-dose computer tomography (LDCT) of thorax. The National Lung Screening Trial in US and the NELSON trial in Europe demonstrated reduction in lung cancer mortality with LDCT screening for lung cancer. In Hong Kong, however, there is a prominence of female never-smokers with lung cancer. There is no identifiable risk factors for non-smokers with lung cancer except family history of lung cancer. The hypothesis is that lung cancer screening for subjects with family history of lung cancer, can detect early lung cancer.
详细描述
The primary aim of this prospective study is to find out the rate of lung cancer detection in subjects who are first degree relatives of lung cancer patients. Secondary aims include studying the characteristics of screen-detected lung cancer. This is a multi-centered prospective cohort study. 1,520 subjects who are first degree relatives of lung cancer patients at four public hospitals in Hong Kong will be screened. Intervention Detailed questionnaires and LDCT Thorax will be performed. The primary outcome measure is the number of lung cancers detected by this study. The screening-detection rate of lung cancer in first-degree relatives of lung cancer patients will be estimated.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 50 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 50-75, men or women, smokers or non-smokers
- •Being first degree relatives (Siblings, children, and parents) of lung cancer subjects
- •Having no known lung cancer before
排除标准
- •Non-Chinese
- •Mentally incompetent to give informed consent
结局指标
主要结局
The rate of lung cancer detection in subjects with family history of lung cancer
时间窗: An average of 2.5 years
The number of screening-detected lung cancer among first degree relatives of lung cancer patients.
次要结局
- The characteristics of screening detected lung cancer(An average of 2.5 years)