Cardiac-Control Affecting Learning Through Mindfulness (CALM)
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 240
- 试验地点
- 2
- 主要终点
- Change in plasma amyloid-beta 42 levels
研究概览
简要总结
Some types of meditation lead heart rate to become more steady as breathing quiets whereas others lead to large heart rate swings up and down (oscillations) as breathing becomes deeper and slower. The current study is designed to investigate how daily mindfulness practice with heart rate biofeedback during breathing in a pattern that either increases or decreases heart rate oscillation affect attention and memory and blood biomarkers associated with Alzheimer's disease.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 50 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
研究组 & 干预措施
Increase Oscillation
Participants will breath at a slow "resonance" frequency during a breath-focused mindfulness practice and receive biofeedback to increase heart rate oscillation.
干预措施: Daily practice (Behavioral)
Decrease Oscillation
Participants' breathing will not be fixed to particular frequency during a breath-focused mindfulness practice and they will receive biofeedback to decrease heart rate oscillation.
干预措施: Daily practice (Behavioral)
结局指标
主要结局
Change in plasma amyloid-beta 42 levels
时间窗: Week 1 and Week 10
Plasma Ab42 levels will be compared for Week 1 (pre-intervention) and Week 10 (post-intervention). Investigators will test for a time X condition interaction in plasma Ab 42 levels (to assess group differences in change).
次要结局
- Plasma amyloid-beta 40 levels(Week 1 and Week 10)
- Plasma Ab42/40 ratio(Week 1 and Week 10)
- Plasma pTau-181/tTau ratio(Week 1 and Week 10)
- Change in brain perivascular space volume(Week 1 and Week 10)
- Brain training performance on Lumosity games during the breathing intervention(During intervention (daily during Weeks 2-10) and before intervention (daily during Week 1))
研究者
Mara Mather
Professor
University of Southern California