ACTRN12622001055796尚未招募1 期
HypErtensive Augmentation with metaraminol During acute ischaemic STroke Assisting Reperfusion Therapies
试验速览
- 阶段
- 1 期
- 状态
- 尚未招募
- 入组人数
- 25
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Non-randomised trial
- 主要目的
- Treatment
入排标准
- 年龄范围
- 18 Years 至 o limit（—）
- 性别
- All
入选标准
- •1) Acute anterior circulation ischaemic stroke with measurable neurologic deficit
- •2) Demonstration of penumbra of CT perfusion imaging (Delay time (DT) lesion >3 seconds volume > 30 mL, as measured by MiSTAR software)
- •3) Initial systolic blood pressure on ED presentation below 160mmHg
排除标准
- •1) Known renal failure (eGFR < 30mL)
- •2) Iodine contrast hypersensitivity
- •3) Any contraindication to Metaraminol administration ((hypersensitivity to Metaraminol including sulfite allergy, nonselective Monoamine Oxidase Inhibitor (MAO-I) therapy (phenelzine, tranylcypromine) in the past 14 days))
- •4) <50 years old
- •5) Previous intracerebral or subarachnoid haemorrhage
- •6) Presence of an intracranial aneurysm or arteriovenous malformation
- •7) Presence of an aortic dissection
- •8) Presence of an acute or recent (<30 days) myocardial infarction
- •9) Recent (<1 month) left ventricular failure
- •10) Any other condition which, in the opinion of the Investigator, increases the risk of blood pressure augmentation
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