NL-OMON34748已完成不适用
A comparative in vitro study on the effects of the product Citrus e fructibus / Cydonia e fructibus as a whole and the single agent drugs Citrus e fructibus and Cydonia e fructibus separately, on immunological parameters of seasonal allergic rhinitis - In vitro effects of Citrus/Cydonia versus only Citrus or only Cydonia
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 10
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •SAR patients:
- •Written informed consent
- •Sex: both men and women
- •Age >= 18 and < 60 years
- •Seasonal allergic rhinitis:
- •*Duration of at least 2 years
- •*High RAST grass pollen (>= 2) and high RAST birch pollen (>= 2)
- •*Suffering from the following nasal symptoms during the pollen season: sneezing, itching nose, nasal obstruction and watery nasal discharge
- •*Severity score of at least three of the four symptoms >= 2 (ranging from 0 = not present to 3= severe)
- •*The necessity to use antihistamines and/or corticosteroids for treatment of symptoms for previous (at least two) years.;Healthy volunteers:
- •Written informed consent
- •Sex: both men and women
- •Age >= 18 and < 60 years
- •RAST for grass and birch pollen = 0
- •Absence of the following nasal symptoms during the pollen season: sneezing, itching nose, nasal obstruction and watery nasal discharge
- •No history of SAR symptoms for at least 2 years
排除标准
- •SAR Patients:
- •Chronic inflammatory autoimmune disease such as Type I - Diabetes Mellitus, Rheumatoid Arthritis, Multiple Sclerosis, Psoriasis or Crohn*s disease
- •Allergic (hypersensitive) to one of the constituents of Citrus e fructibus / Cydonia e fructibus
- •Use of other preparations containing Citrus and/or Cydonia extracts within the last two weeks prior to enrolment into the study
- •Use of cromoglycates in the last month before study onset
- •Concomitant pharmacological treatment indicated for seasonal allergic rhinitis such as antihistamines, corticosteroids or other preparations in the last two weeks before study onset
- •Anti-allergy immunotherapy in previous years
- •Participation in a further clinical trial at the same time or within the previous 4 weeks prior to enrolment into this study
- •Pregnancy or lactation
- •Severe internal or systemic disease ( e.g. cardiac, hepatic, renal diseases)
- •A known history of drug, alcohol and/or medication dependence or addiction;Healthy volunteers:
- •Chronic inflammatory autoimmune disease such as Type I - Diabetes Mellitus, Rheumatoid Arthritis, Multiple Sclerosis, Psoriasis or Crohn*s disease
- •Allergic (hypersensitive) to one of the constituents of Citrus e fructibus / Cydonia e fructibus
- •Participation in a further clinical trial at the same time or within the previous 4 weeks prior to enrolment into this study
- •Pregnancy or lactation
- •Severe internal or systemic disease ( e.g. cardiac, hepatic, renal diseases)
- •Drug, alcohol and/or medication dependence or addiction
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