NCT07634328进行中（未招募）不适用
Impact of a High-Protein Diet on Clinical Outcomes in Mechanically Ventilated Patients With Severe Pneumonia
适应症
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 60
- 试验地点
- 1
研究概览
简要总结
prospective, comparative, observational study will be conducted at the Critical Care Department, Fayoum University Hospital, to evaluate the impact of a high-protein diet versus a standard-protein diet in mechanically ventilated patients with severe pneumonia.
详细描述
prospective, comparative, observational study will be conducted at the Critical Care Department, Fayoum University Hospital, aims to evaluate the effect of a high-protein diet on clinical outcomes in mechanically ventilated patients with severe pneumonia, focusing on muscle preservation and weaning ability. The specific objectives are:
- To assess the impact of high-protein intake on skeletal muscle mass using quadriceps ultrasound.
- To evaluate diaphragmatic function and thickness in relation to protein intake using ultrasound.
- To determine the effect of high-protein nutrition on weaning success, duration of mechanical ventilation, length of hospital stay and mortality.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥ 18 years.
- •Mechanically ventilated patients with severe pneumonia.
- •Expected ICU stay ≥ 72 hours.
排除标准
- •Patients who died before 72 hours of ICU admission.
- •Chronic liver failure or decompensated cirrhosis.
- •End-stage renal disease (CKD stage 5 or dialysis dependent).
- •Neuromuscular diseases or pre-existing severe muscle wasting.
- •Pregnancy.
- •Patients with pre-existing malnutrition (e.g., BMI <18.5 kg/m² ).
- •Contraindications to enteral feeding, such as:
- •Mechanical bowel obstruction.
- •Severe gastrointestinal bleeding.
- •High-output fistulas involving the gastrointestinal tract.
- •Recent gastrointestinal surgery preventing enteral access.
研究者
Mahmoud Abdelnabi Abdelhalim Ahmed
Teaching Assistant of Critical Care Medicine Department
Fayoum University
研究点 (1)
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