Analyse de l'Effet Des caractéristiques de concentrés Plaquettaires Sur le Rendement Transfusionnel Chez Les Patients Ayant Une hémopathie Maligne et bénéficiant de Transfusions Plaquettaires à Titre Prophylactique
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 1,101
- 主要终点
- Corrected count increment
研究概览
简要总结
Platelet concentrates (PCs) characteristics, such as storage duration, ABO compatibility, dose and source, may have an impact on transfusion responses and outcomes. Because of the relative scarcity of PCs the selection of a specific PC for issue to the patient remains a challenging process. Regulatory agencies do not fully address these characteristics in their recommendations for prophylactic transfusions.
The aim of the study was to analyse the effect of product-related factors in a real life setting, in order to determine which ones are the most relevant when selecting PCs for patients in prophylactic conditions. Two different endpoints are studied: the corrected count increment and the platelet transfusion time intervals.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Inpatients in the hematology department between January 2001 and December 2012
- •Hematologic malignancy
- •At least one platelet transfusion (with platelet count ≤ 25 G/L)
- •Age 18 and over at time of first transfusion
排除标准
- •More than one hematologic malignancy
- •Non-malignant haematological disorder
结局指标
主要结局
Corrected count increment
时间窗: 24 hours post transfusion
Platelet increment corrected for platelet dose and body surface area
次要结局
- Transfusion interval(7 days)