NCT05244694已完成早期 1 期
Impact of Insulin on Sympathetic Nervous System-mediated Peripheral Vasoconstriction
适应症
干预措施
相关药物
试验速览
- 阶段
- 早期 1 期
- 状态
- 已完成
- 入组人数
- 28
- 试验地点
- 1
- 主要终点
- Amount of leg blood flow
研究概览
简要总结
The purpose of this project is to determine if hyperinsulinemia attenuates sympathetic nervous system-mediated vasoconstriction in the human leg.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •healthy adult men and women;
- •18-45 years of age;
- •BMI 18-30 kg/m2;
- •non-pregnant/non-breastfeeding;
- •non-nicotine users;
排除标准
- •taking any medications known to affect metabolic, respiratory, cardiovascular, and/or autonomic functions
- •Self-reported history of:
- •hepatic, renal, pulmonary, cardiovascular, or neurological disease;
- •stroke or neurovascular disease;
- •bleeding/clotting disorders;
- •sleep apnea or other sleep disorders;
- •diabetes;
- •history of alcoholism or substance abuse, excessive alcohol consumption;
- •hypertension;
- •active cancer;
- •autoimmune disease;
- •immunosuppressant therapy
研究组 & 干预措施
Insulin
Experimental
Participants will complete a 60 minute hyperinsulinemic-euglycemic infusion.
干预措施: Insulin (Drug)
结局指标
主要结局
Amount of leg blood flow
时间窗: Change from baseline at minute 60
Measured with Doppler ultrasound (mL/min)
次要结局
- Amount of cerebral blood flow(Change from baseline at minute 60)
- Amount of muscle sympathetic nerve activity (MSNA)(Change from baseline at minute 60)
研究者
Jacqueline K Limberg, PhD
Assistant Professor
University of Missouri-Columbia
研究点 (1)
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