Sedation Practice in Intensive Care Evaluation (SPICE IV) Early Sedation With Dexmedetomidine vs. Placebo in Older Ventilated Critically Ill Patients: A Prospective, Multi-Centre, Double-Blind, Randomized, Controlled Trial
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- Mortality
研究概览
简要总结
Sedation remains a ubiquitous and crucial component of intensive care treatments in critically ill mechanically ventilated patients. Sedation relieves anxiety, reduces distress, and promotes tolerance of endotracheal intubation and associated life-sustaining interventions such as mechanical ventilation, cardiovascular assistance, and renal support. Thus, choosing the optimal sedative agent is vital to patient comfort, safety, and survival. Despite more than 20 years of intensive care sedation research, there is still no consensus on what constitutes best sedation practice. The Society of Critical Care Medicine, the premier critical care organisation in North America, published the 2018 Clinical Practice Guidelines on the management of Pain, Agitation/Sedation, Delirium, Immobility and Sleep (PADIS) disruption (chaired by our primary applicant W.A.) and issued weak recommendations to provide analgesia before sedation, to target light sedation whenever clinically feasible, and to use either dexmedetomidine or propofol over midazolam for the sedation of mechanically ventilated critically ill patients. Similarly, the American Thoracic Society produced a set of Clinical Practice Guidelines to promote liberation and weaning from mechanical ventilation in critically ill patients, with weak recommendations for the use of non-benzodiazepines as primary sedatives and to target light sedation when clinically possible. A weak recommendation was issued in an Intensive Care Medicine Rapid Practice Guideline published in 2022 to use dexmedetomidine over propofol for sedation of critically ill adults, if the desired outcome is a reduction in delirium. These guidelines, however, do not consider age-dependent pharmacokinetics and pharmacodynamics, illness severity, timing of sedative administration, operative vs medical reason for admission, or the changing dynamics of sedation practice at different phases of critical illness. The lack of high-level evidence to inform sedation practice in the critically ill has led to approaches that are mainly opinion-based and lack the support of evidence from large multicentre, international randomised clinical trials.
详细描述
- BACKGROUND
Current guidelines highlight evidence gaps to be addressed in future sedation trials, particularly the need for adequately powered trials to evaluate impact of sedative choice in older adults, as they have a highest overall mortality and the most common demographic to require an ICU admission of all age groups.
Dexmedetomidine, an α2-adrenergic agonist sedative, may be the solution. The SPICE III trial, a prelude to the SPICE IV study, evaluated early sedation with dexmedetomidine versus usual care sedation in 4000 critically ill patients. The SPICE III trial identified a heterogeneity of treatment effect (HTE) on the primary outcome of 90-day mortality, suggesting lower mortality in older patients. To further evaluate the observed HTE, SPICE IV was designed as a randomized double-blind placebo-controlled trial with a study population restricted to patients at or older than 65 years of age. 2. HYPOTHESIS
Early sedation with DEX as the primary sedative agent reduces 90-day all-cause mortality in invasively mechanically ventilated patients who are ≥ 65 years of age. 3. OBJECTIVES
The primary aim is to determine whether, in invasively mechanically ventilated patients who are ≥ 65 years of age, early sedation with DEX as the primary sedative agent reduces 90-day all-cause mortality.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
盲法说明
To maintain blinding of patients, investigators, clinical staff, and research coordinators, pre-packaged study medication kits will be used. Upon randomization, the website will assign a unique study number and a unique 'medication kit number' to each participant. The unique medication kit number is matched to blinded study drug according to the patient's treatment allocation, supplied to the site. Each medication kit will contain either: dexmedetomidine 200 µg/2 ml vials or normal saline vials. Blinding of study medications within the medication kit will be achieved by identical labelled 2 ml vials.
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥ 65 years
- •Intubated and receiving invasive mechanical ventilation in an intensive care unit
- •The treating clinicians believe that the patient will remain intubated and ventilated until the day after tomorrow (i.e. unlikely to be extubated the following day)
- •The patient requires immediate ongoing sedative medication for comfort, safety and to facilitate the delivery of life support measures.
排除标准
- •Has been intubated (excluding time spent intubated within an operating theatre or transport) for greater than 12 hours, with an additional 6-hour grace period, a total of 18 hours, in an intensive care unit
- •Proven or suspected acute primary brain lesion such as traumatic brain injury, haemorrhage, stroke, or hypoxic brain injury
- •Proven or suspected spinal cord injury or other pathology that may result in permanent or prolonged weakness
- •Admission as a consequence of a suspected or proven drug overdose or burns
- •Administration of or need for ongoing neuromuscular blockade
- •A mean arterial blood (MAP) pressure that is less than 50 mmHg, despite adequate resuscitation and vasopressor support at time of randomization
- •Heart rate less than 55 beats per minute or a high grade atrio-ventricular block in the absence of a functioning pacemaker
- •Known sensitivity to dexmedetomidine
- •Acute fulminant hepatic failure with EITHER
- •hepatic encephalopathy OR
- •bilirubin (>300 µmol/l) and INR (>3.5), or both, without prior hepatic dysfunction.
- •Receiving full time residential nursing care
- •Death is deemed both imminent and inevitable and either the attending physician, patient or substitute decision maker is not committed to active treatment
- •Underlying disease that makes survival to 90 days unlikely
- •Previously enrolled in the SPICE IV study
研究组 & 干预措施
Dexmedetomidine Intervention
Patients randomized to the experimental arm will receive dexmedetomidine. The study medication will be reconstituted by mixing 4 vials (8 ml) into a 100 ml bag of normal saline or 5% dextrose, this is the preferred dilution, or 2 vials (4ml) into 50 ml syringe to an equivalent concentration of 8 mcg/ml of dexmedetomidine. The constituted infusion is stable at room temperature for up to 24 hours.
The recommended starting infusion rate is equivalent to 1 µg/kg/h of dexmedetomidine, without loading or bolus. This will be titrated to an equivalent dexmedetomidine dose of 0 to 1.0 µg/kg/h according to study algorithm to maintain target sedation of Richmond Agitation-Sedation Scale (RASS) score of -1 to +1.
干预措施: Dexmedetomidine (Drug)
Control Intervention
Those in the control group will receive a placebo that is identical in colour and packaging and at equal volume to the intervention group. The placebo is a matching vial containing 2 mL sterile normal saline.
干预措施: Placebo (Other)
结局指标
主要结局
Mortality
时间窗: 90 days
90-day all-cause mortality
次要结局
- Number of days alive and free of coma and delirium(28 days)
- Number of days alive and ventilator free(28 days)
- Major Adverse Kidney Events(28 days)
- Duration of mechanical ventilation in survivors(28 days)
- Hospital Length of Stay in survivors(28 days)
研究者
Kimberley Lewis
Principal Investigator
St. Joseph's Healthcare Hamilton