cAMP Signaling and Muscle Adaptations
试验速览
- 阶段
- 不适用
- 入组人数
- 72
- 试验地点
- 2
- 主要终点
- Muscle hypertrophy (lean body mass in Kilograms)
研究概览
简要总结
The role of cAMP signaling mediated by beta2-adrenergic stimulation with agonists has been well-studied in skeletal muscles of animals. Studies in humans are scant and the scope of the present study is thus to investigate the role of cAMP signaling by beta2-adrenergic stimulation for muscle adaptations in humans.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •healthy young men
- •18-35 years of age
- •Informed consent
- •Active 2-5 hours of training pr. week
- •Maximal oxygen uptake (ml/min/kg) of 40-60
- •Lean body mass of 55-65 kg / Lean mass index 14-22 kg/m2
排除标准
- •Allergy towards study drugs
- •Chronic disease
研究组 & 干预措施
Terbutaline
Beta2-adrenergic stimulation with terbutaline
干预措施: Endurance training (Other)
Clenbuterol
Beta2-adrenergic stimulation with clenbuterol
干预措施: Clenbuterol (Drug)
Terbutaline
Beta2-adrenergic stimulation with terbutaline
干预措施: No training (Other)
Terbutaline
Beta2-adrenergic stimulation with terbutaline
干预措施: Resistance Training (Other)
Terbutaline
Beta2-adrenergic stimulation with terbutaline
干预措施: Terbutaline (Drug)
Placebo
Placebo
干预措施: No training (Other)
Placebo
Placebo
干预措施: Endurance training (Other)
Placebo
Placebo
干预措施: Resistance Training (Other)
Placebo
Placebo
干预措施: Placebo (Drug)
Clenbuterol
Beta2-adrenergic stimulation with clenbuterol
干预措施: No training (Other)
结局指标
主要结局
Muscle hypertrophy (lean body mass in Kilograms)
时间窗: 2 days
Lean body mass (kg) will be measured at two different days by Dual X-ray absorbance (DXA)
次要结局
- Energy turnover (ml/min or mmol/kg dry weight muscle)(1 day)
研究者
Morten Nielsen
Post.Doc
University of Copenhagen