Evaluating the efficacy of low dose oral minoxidil Post Hair Transplant, in patterned hair loss: A Prospective Study
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- To evaluate the efficacy of oral minoxidil in post hair transplantation patients.
研究概览
简要总结
Androgenetic alopecia (AGA), colloquially known as male or female pattern baldness, is a hereditary condition characterized by progressive hair thinning and loss. It is the most common cause of hair loss, affecting both men and women. AGA results from a complex interplay of genetic and hormonal factors, particularly the influence of androgens like dihydrotestosterone (DHT) on susceptible hair follicles. The psychological impact of AGA can be profound, affecting self-esteem and quality of life. While not curable, various treatments, including topical minoxidil, oral finasteride, and hair transplantation, aim to slow progression or restore hair density (1)
Hair transplantation (HT) is a method of transferring hair follicles from a donor area to a recipient/bald area. The most commonly chosen donor site is the occipital region as the hair in this region is unaffected by AGA. When the hair in the occipital region is scanty or insufficient, facial hair and body hair may be used. The rationale for hair transplantation in AGA is donor dominance, i.e., the transplanted hair continues to be unaffected by the balding process even after relocation to the new site (2). Hair transplantation is a widely adopted solution for androgenetic alopecia, yet postoperative challenges persist, such as delayed growth and donor site scarring.
This research investigates the potential of oral minoxidil in enhancing post-transplantation outcomes. Recognizing the need for adjunctive therapies, we explore the rationale behind incorporating oral minoxidil, initially a vasodilator, and its impact on graft survival, growth acceleration, and overall patient satisfaction.
Minoxidil is the only other drug that is approved by the USFDA for the treatment of AGA. After conversion to its active form, i.e., minoxidil sulphate, it acts on the receptors on arterial smooth muscle cells to cause vasodilatation. This leads to a prolonged anagen of the miniaturized hair follicle and reduced shedding
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 盲法
- None
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •All male patients who undergo hair transplantation following no response to conventional therapies Patient consenting for study.
排除标准
- •Patient with history of cardio vascular diseases Patients with chronic renal diseases Patient with history of hypotension Patient taking medications like aspirin, blood thinners and guanethidine.
结局指标
主要结局
To evaluate the efficacy of oral minoxidil in post hair transplantation patients.
时间窗: After 6 months
To assess the safety and adverse effects associated low dose oral minoxidil.
时间窗: After 6 months
To evaluate patient satisfaction and subjective perceptions of treatment outcome.
时间窗: After 6 months
次要结局
- Efficacy will be evaluated by hair counts, hair diameter measurements, anagen telogen ratio photographic assessment by trichoscan(After 6 months)
研究者
Dr Megha C
CUTIS Academy of Cutaneous Sciences