Development of Maternal Voice Recognition in Preterm Neonates
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 22
- 试验地点
- 1
- 主要终点
- The difference in amplitude
研究概览
简要总结
Many cognitive functions in humans are based on asymmetrical brain networks. For example, in most adults, the language is essentially processed by the left hemisphere, while other auditory functions, such as voice recognition, tend to be processed by the right hemisphere. Many studies, especially those conducted by Ghislaine Dehaene's team, have demonstrated the presence of anatomical and functional asymmetries by the first months of life. What are the causes of these asymmetries? How do they develop? Are they necessary for functioning or effective learning?
This study, conducted in collaboration with the Compiègne applied mathematics team (Abdelatif El Badia) and the INSERM team (Ghislaine Dehaene), is designed to determine the stage of development at which hemispheric dominance for voice recognition is first observed and to identify the brain structure involved in preterm neonates whose sound environment is usually very different from that of the foetus. The impact of this environment on the infant's brain development and early learning will be evaluated.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 0 Days 至 6 Days（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •The distribution of children in the different groups of infants included in the study will be validated at the time of the acquisitions.
- •Normal group of children: A child meets the age criteria and without ductus arteriosus persistence ultrasound or detectable neurological disorders after clinical, neurophysiological and radiological (ETF, Scanner, MRI).
- •Group of children meet the age criteria and with cerebral neurological pathology detectable after clinical, neurophysiological and radiological (ETF, Scanner, MRI).
排除标准
- •About history:
- •All children with severe congenital malformation
- •Regarding the study period;
- •Any refusal of a parent
- •Children with severe impairment of the general condition and vital functions
- •Children with dermatitis of the face or scalp
- •Children treated with ventilation High Frequency (HFO)
- •Presence of intravenous access on the scalp (preventing the realization of the ETF, EEG and NIRS
研究组 & 干预措施
Normal children
Every child meet the age criteria and without ductus arteriosus persistence ultrasound or detectable neurological disorders after clinical, neurophysiological and radiological
干预措施: electroencephalogram (HR-EEG) (Device)
Normal children
Every child meet the age criteria and without ductus arteriosus persistence ultrasound or detectable neurological disorders after clinical, neurophysiological and radiological
干预措施: Near Infra Red Spectroscopy (NIRS) (Device)
Abnormal children
Every child meet the criteria of age and having a detectable neurological disease after clinical, neurophysiological and radiological as intraventricular hemorrhage .
干预措施: electroencephalogram (HR-EEG) (Device)
Abnormal children
Every child meet the criteria of age and having a detectable neurological disease after clinical, neurophysiological and radiological as intraventricular hemorrhage .
干预措施: Near Infra Red Spectroscopy (NIRS) (Device)
结局指标
主要结局
The difference in amplitude
时间窗: 10 weeks
The difference in amplitude of the electrical hemodynamic responses to stimuli depending on the conditions, which corresponds to the evoked potential mismatch Response
The difference in latency
时间窗: 10 weeks
The difference in latency of the electrical hemodynamic responses to stimuli depending on the conditions, which corresponds to the evoked potential mismatch Response
次要结局
未报告次要终点