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临床试验/NCT01245309
NCT01245309已完成早期 1 期

Endometrial Injury Prior to Controlled Ovarian Stimulation (COH) in Women Undergoing In-vitro Fertilization in Women With Previous IVF Failure.

Mansoura University2 个研究点 分布在 1 个国家目标入组 500 人开始时间: 2010年12月最近更新:
适应症

试验速览

阶段
早期 1 期
状态
已完成
入组人数
500
试验地点
2
主要终点
live birth rate per woman

研究概览

简要总结

Scratching the linning of the womb before IVF cycle could increase the chances of having a baby after an IVF cycle.

详细描述

All women with history of RIF (as defined by ESHRE) and who wish to undertake another assisted conception treatment cycle are invited to participate in the trial. Women will be randomised to two arms; one undergoing endometrial sampling and control. Women in the experimental arm will be subjected to endometrial scrapping with Pipelle biopsy catheter two times; on days 21 and 26 of the cycle prior to the IVF index cycle and after initiation of the GnRHa in the long agonist protocol. Women in the control group will undergo a placebo procedure using the uterine sound on the same days of the cycle like women in the intervention group.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
Triple (Participant, Investigator, Outcomes Assessor)

入排标准

年龄范围
— 至 40 Years(Child, Adult)
性别
Female
接受健康志愿者

入选标准

  • WOMEN WITH PREVIOUS IVF FAILURE UNDERGOING IVF TREATMENT

排除标准

  • WOMEN>40 YEARS OLD WOMEN UNDERGOING THEIR FIRST IVF TREATMENT CYCLE

结局指标

主要结局

live birth rate per woman

时间窗: 9 months

次要结局

  • ongoing pregnancy rate(12 weeks)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Ahmed Gibreel

Dr

Mansoura University

研究点 (2)

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