Endometrial Injury Prior to Controlled Ovarian Stimulation (COH) in Women Undergoing In-vitro Fertilization in Women With Previous IVF Failure.
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 500
- 试验地点
- 1
- 主要终点
- live birth rate per woman
研究概览
简要总结
Scratching the linning of the womb before IVF cycle could increase the chances of having a baby after an IVF cycle.
详细描述
All women with history of RIF (as defined by ESHRE) and who wish to undertake another assisted conception treatment cycle are invited to participate in the trial. Women will be randomised to two arms; one undergoing endometrial sampling and control. Women in the experimental arm will be subjected to endometrial scrapping with Pipelle biopsy catheter two times; on days 21 and 26 of the cycle prior to the IVF index cycle and after initiation of the GnRHa in the long agonist protocol. Women in the control group will undergo a placebo procedure using the uterine sound on the same days of the cycle like women in the intervention group.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- — 至 40 Years（Child, Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •WOMEN WITH PREVIOUS IVF FAILURE UNDERGOING IVF TREATMENT
排除标准
- •WOMEN>40 YEARS OLD WOMEN UNDERGOING THEIR FIRST IVF TREATMENT CYCLE
研究组 & 干预措施
PLACEBO
PLACEBO PROCEDURE
干预措施: A PLACEBO PROCEDURE (Procedure)
scratching
endometrial scratching prior ivf cycle
干预措施: scratching (Procedure)
scratching
endometrial scratching prior ivf cycle
干预措施: A PLACEBO PROCEDURE (Procedure)
结局指标
主要结局
live birth rate per woman
时间窗: 9 months
次要结局
- ongoing pregnancy rate(12 weeks)