Pulmonary Diffusing Capacity to Nitric Oxide and Carbon Monoxide During Exercise in Patients With Chronic Obstructive Pulmonary Disease: a Test-retest Reliability Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 15
- 试验地点
- 2
- 主要终点
- CV for VA at rest
研究概览
简要总结
The combined measurement of the pulmonary diffusing capacity to carbon monoxide (CO) and nitric oxide (NO) (DLCO/NO) during exercise may be a useful physiological measure of alveolar-capillary reserve in patients with Chronic obstructive pulmonary disease (COPD). The present study investigated the test-retest reliability of DLCO/NO-based metrics.
详细描述
The combined measurement of the pulmonary diffusing capacity to carbon monoxide (CO) and nitric oxide (NO) (DLCO/NO) has recently been standardised and validated for clinical use. It is thus ideal for assessing acute changes in pulmonary diffusing capacity and its components during various physiological manoeuvres. These changes are thought to involve acute changes in pulmonary perfusion and are notably relevant for patients with chronic obstructive pulmonary disease (COPD), in which they may be related to exertional dyspnoea. The aim of the present study is to investigate the effects of acute exercise on pulmonary diffusing capacity, and to determine the day-to-day repeatability of such assessments.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Chronic obstructive pulmonary disease (GOLD II + III)
排除标准
- •Known heart disease
- •Pregnancy
- •Disease within two weeks prior to inclusion
研究组 & 干预措施
Acute exercise
Pulmonary diffusing capacity using the DLCO/NO technique is assessed at rest and during exercise (60% of maximal workload on a bicycle ergometer)
干预措施: Acute exercise (Diagnostic Test)
结局指标
主要结局
CV for VA at rest
时间窗: Measured at day 1 and day 2
CV with 95% CI for VA at rest
CV for VA during exercise
时间窗: Measured at day 1 and day 2
CV with 95% CI for VA during exercise
ICC for DLCOc at rest
时间窗: Measured at day 1 and day 2
ICC for DLCOc with 95% CI at rest
Intraclass correlation coefficient (ICC) for DLNO during exercise
时间窗: Measured at day 1 and day 2
ICC for DLNO with 95% CI during exercise
Rest-to-exercise change in DLNO
时间窗: Measured at day 1 and day 2
The physiological change from rest to exercise in DLNO obtained using the combined DLCO/NO technique with a 5-sec breathhold.
Rest-to-exercise change in DM
时间窗: Measured at day 1 and day 2
The physiological change from rest to exercise in DM obtained using the combined DLCO/NO technique with a 5-sec breathhold.
CV for DM at rest
时间窗: Measured at day 1 and day 2
CV with 95% CI for DM at rest
SRD for Diffusion capacity for carbon monoxide (DLCOc) at rest
时间窗: Measured at day 1 and day 2
SRD with 95% CI for DLCOc at rest
Rest-to-exercise change in VC
时间窗: Measured at day 1 and day 2
The physiological change from rest to exercise in VC obtained using the combined DLCO/NO technique with a 5-sec breathhold.
Rest-to-exercise change in VA
时间窗: Measured at day 1 and day 2
The physiological change from rest to exercise in VA obtained using the combined DLCO/NO technique with a 5-sec breathhold.
SRD for DLNO during exercise
时间窗: Measured at day 1 and day 2
SRD with 95% CI for DLNO during exercise
SRD for DLCOc during exercise
时间窗: Measured at day 1 and day 2
SRD with 95% CI for DLCOc during exercise
SRD for Pulmonary blood volume (Vc) at rest
时间窗: Measured at day 1 and day 2
SRD with 95% CI for Vc at rest
SRD for VA during exercise
时间窗: Measured at day 1 and day 2
SRD with 95 % CI for VA during exercise
CV for DLNO during exercise
时间窗: Measured at day 1 and day 2
CV with a 95% CI during exercise
CV for DLCOc during exercise
时间窗: Measured at day 1 and day 2
CV with 95% CI for DLCOc during exercise
CV for DM during exercise
时间窗: Measured at day 1 and day 2
CV with 95% CI for DM during exercise
CV for Vc at rest
时间窗: Measured at day 1 and day 2
CV with 95% CI for DM at rest
CV for Vc during exercise
时间窗: Measured at day 1 and day 2
CV with 95% CI for DM during exercise
Intraclass correlation coefficient (ICC) for DLNO at rest
时间窗: Measured at day 1 and day 2
ICC for DLNO with 95% CI at rest
Rest-to-exercise change in DLCOc
时间窗: Measured at day 1 and day 2
The physiological change from rest to exercise in DLCOc obtained using the combined DLCO/NO technique with a 5-sec breathhold.
Smallest real difference (SRD) for Diffusion capacity for DLNO at rest
时间窗: Measured at day 1 and day 2
SRD with 95 % confidence intervals (95% CI) for DLNO at rest
SRD for membrane diffusing capacity (DM) at rest
时间窗: Measured at day 1 and day 2
SRD with 95% CI for DM at rest
SRD for DM during exercise
时间窗: Measured at day 1 and day 2
SRD with 95% CI for DM during exercise
SRD for Vc during exercise
时间窗: Measured at day 1 and day 2
SRD with 95% CI for Vc during exercise
SRD for alveolar volume (VA) at rest
时间窗: Measured at day 1 and day 2
SRD with 95 % CI for VA at rest
Coefficient of Variance (CV) for DLNO at rest
时间窗: Measured at day 1 and day 2
CV with a 95% CI at rest
CV for DLCOc at rest
时间窗: Measured at day 1 and day 2
CV with 95% CI for DLCOc at rest
ICC for VC at rest
时间窗: Measured at day 1 and day 2
ICC for VC with 95% CI at rest
ICC for DLCOc during exercise
时间窗: Measured at day 1 and day 2
ICC for DLCOc with 95% CI during exercise
ICC for DM at rest
时间窗: Measured at day 1 and day 2
ICC for DM with 95% CI at rest
ICC for VC during exercise
时间窗: Measured at day 1 and day 2
ICC for VC with 95% CI during exercise
ICC for VA during exercise
时间窗: Measured at day 1 and day 2
ICC for VA with 95% CI during exercise
ICC for DM during exercise
时间窗: Measured at day 1 and day 2
ICC for DM with 95% CI during exercise
ICC for VA at rest
时间窗: Measured at day 1 and day 2
ICC for VA with 95% CI at rest
次要结局
- Breath hold time during exercise(Measured at day 1 and day 2)
- Alveolar volume (VA) during exercise(Measured at day 1 and day 2)
- Diffusion capacity for carbon monoxide (DLCOc) during exercise(Measured at day 1 and day 2)
- Membrane diffusing capacity (DM) during exercise(Measured at day 1 and day 2)
- Bland Altman Plot - DLNO(Measured at day 1 and day 2)
- Bland Altman Plot - DM(Measured at day 1 and day 2)
- Bland Altman Plot - VA(Measured at day 1 and day 2)
- Diffusion capacity for nitric oxide (DLNO) at rest(Measured at day 1 and day 2)
- Diffusion capacity for carbon monoxide (DLCOc) at rest(Measured at day 1 and day 2)
- Membrane diffusing capacity (DM) at rest(Measured at day 1 and day 2)
- Pulmonary blood volume (Vc) at rest(Measured at day 1 and day 2)
- Pulmonary blood volume (Vc) during exercise(Measured at day 1 and day 2)
- Breath hold time at rest(Measured at day 1 and day 2)
- Diffusion capacity for nitric oxide (DLNO) during exercise(Measured at day 1 and day 2)
- Alveolar volume (VA) at rest(Measured at day 1 and day 2)
- Bland Altman Plot - DLCOc(Measured at day 1 and day 2)
- Bland Altman Plot - VC(Measured at day 1 and day 2)
研究者
Ronan Berg
MD, DMSc, Associate Professor, Principal investigator
Rigshospitalet, Denmark