Synchronizing Blastocyst at Hatching Stage in Frozen Embryo Transfer Cycles
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 742
- 试验地点
- 2
- 主要终点
- Ongoing implantation rate
研究概览
简要总结
The aim of the present study is to determine if implantation rate could be increased in women undergoing frozen embryo transfer cycles in case of adjusting their embryo development at hatching stage.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Double (Participant, Care Provider)
盲法说明
The gynecologist performing the embryo transfer as well as the patients undergoing frozen embryo transfer will be blinded to group allocation
入排标准
- 年龄范围
- 19 Years 至 33 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Patients who will agree to participate and assign an informed consent form
- •Only blastocyst transfer FET cycles
- •Patients undergoing FET after their 1st IVF or ICSI cycle with no pregnancy at the fresh transfer
- •Freeze-all cycles due to OHSS
- •Freeze-all cycles due to poor endometrium
- •Age 19-33 at the time of randomization.
- •Their frozen blastocysts are 3 or less grade of expansion.
- •Female with a ≥12 AFCs
- •Endometrial thickness ≥ 8mm at the time of ovulation
- •Women with their male partners will give only fresh semen
- •Women who have no uterine abnormality by ultrasound
排除标准
- •Cycles undergoing preimplantation genetic diagnosis.
- •Women who have previous two cycles of implantation failure at fresh transfer
- •Women who have previous two FET failed cycles
- •Any uterine pathology (myomas, adenomyosis, endocrinopathies, thrombophilia, chronic pathologies, acquired or congenital uterine abnormalities)
- •Patients with severe endometriosis
- •Presence of uni- or bilateral hydrosalpinx
- •Recurrent pregnancy loss.
- •Any medical condition that affect fertility.
研究组 & 干预措施
frozen/thawed
blastocysts with three or less grade of expansion will be thawed and then subsequently transferred into women uterus three hours post-thawing.
synchronized frozen/thawed hatching blastocysts
blastocyst thawing (with three or less grade of expansion) will take place the day before embryo transfer in order to reach hatching stage
干预措施: synchronizing blastocysts (Other)
结局指标
主要结局
Ongoing implantation rate
时间窗: 12 weeks
ultrasound detection of ongoing gestational sacs with heartbeats after 12 weeks of gestation per transferred embryos
次要结局
未报告次要终点
研究者
Yasmin Magdi
Dr
Al-Yasmeen Fertility and Gynecology Center