NCT00899613Unknown不适用
Study Aiming at Researching Diagnostic Markers for the Recognition of Precancerous States, Tracking, Follow-up, and the Identification of New Therapeutic Targets for Mesothelioma in Patients With Atypical Mesothelial Hyperplasia.
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 270
- 试验地点
- 1
- 主要终点
- Mesothelin and osteopontin concentrations in serum
研究概览
简要总结
RATIONALE: Studying levels of mesothelin and osteopontin in samples of blood from patients with mesothelioma or atypical mesothelial hyperplasia may help doctors identify biomarkers related to cancer.
PURPOSE: This research study is looking at mesothelin and osteopontin as diagnostic markers in patients with mesothelioma or atypical hyperplasia.
详细描述
OBJECTIVES:
Primary
- Determine if mesothelin and osteopontin in serum can serve as early markers of malignant transformation into mesothelioma.
Secondary
- Determine if there are cytological, histological, immunohistochemical, and molecular markers of precancerous disease in tissue samples.
- Determine if SV40 has a carcinogenic role.
- Determine the relationship between the serum concentration of mesothelin and/or osteopontin and the expression of other markers and with clinical progression.
研究设计
- 研究类型
- Observational
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Mesothelin and osteopontin concentrations in serum
次要结局
- Cytological, histological, immunohistochemical, and molecular markers of precancerous disease in tissue samples
- Role of SV40
- Relationship of serum concentration of mesothelin and/or osteopontin with the expression of other markers and with clinical progression
研究者
研究点 (1)
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