The Mechanism Underlying Different Incidence of Post Stroke Depression in Patients with Distinct Chinese Medicine Syndromes of Acute Ischemic Sroke Based on Inflammatory Factors and Gut Microbiota of Brain-Gut Axis

Xuanwu Hospital Capital Medical University0 个研究点开始时间: 待定最近更新: 2023年2月20日

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•1.Aged 45-70 years;
•2.Meeting the diagnostic criterion for cerebral infarction within 72 hours of onset;
•3.Meeting the diagnostic criterion of cerebral infarction for Tan Re Fu Shi or Qi Xu Xue Yu in Traditional Chinese Medicine;
•4.HAMD < 8;
•5.NIHSS 0-15;
•6.mRS 0-2;
•7.Conscious, expressing clearly and able to cooperate with clinicians in the collection of clinical information;
•8.Linving in Beijing;
•9.Informed consent.
•Patients who meet the criterion above simultaneously can be recruited.

•1.WIth a history of depression;
•2.With unstable vital signs;
•3.Cerebral hemorrhage or mixed stroke;
•4.Temporal lobe infarction lesions and with severe aphasia, agnosia, hearing or vision impairment, aphasia or dyslexic speech and cognitive impairment;
•5.With serious diseases;
•6.Alcoholism or substance dependence;
•7.With (a history of) other psychosis or nervous system diseases resulting in impaired cognition;
•8.Refusing or unable to cooperating;
•9.Pregnancy;
•10.With any surgery, medication, food or something that affecting gut microbiota;
•Patients who meet anyone of criterion above should be excluded.

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