CTIS2024-512641-16-00招募中1 期
Efficacy and safety of 72-hour infusion of Prostacyclin (1 ng/kg/min) in mechanically ventilated patients with infectious pulmonary endotheliopathy – a multicentre randomized, placebo-controlled, blinded, investigator-initiated trial” (COMBAT-ARF).
适应症
试验速览
- 阶段
- 1 期
- 状态
- 招募中
- 入组人数
- 450
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional clinical trial of medicinal product
入排标准
- 年龄范围
- 18 至 65+（—）
- 性别
- All
入选标准
- •Adult intensive care patients (aged 18 years or above), Suspected pulmonary infection, Need for mechanical ventilation (< 24hours from time of screening), Endothelial biomarker (sTM) = 4 ng/m
排除标准
- •Withdrawal from active therapy, Septic shock according to Sepsis-3 AND sTM>10 ng/ml, Known hypersensitivity to iloprost or to any of the other ingredients., Previously included in this trial or a prostacyclin trial within 30 days, Life-threatening bleeding defined by the treating physician, Known severe heart failure (NYHA class IV), Suspected acute coronary syndrome, Pregnancy (non-pregnancy confirmed by patient being postmenopausal (age 60 or above) or having a negative urine- or plasma-hCG)
研究者
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