The TRENT-ICU Study (Transfusion Threshold Based on Hemoglobin Trends): Hemoglobin Drop Rate as a Predictor of Adverse Clinical Outcomes in Critically Ill Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 128
- 试验地点
- 1
- 主要终点
- Prolonged Intensive Care Unit Stay
研究概览
简要总结
The goal of this observational study is to evaluate if early absolute hemoglobin decline (during the first 24 hours of admission) can predict prolonged intensive care unit stay (8 days or more) and in-hospital mortality in critically ill adult patients.
The main questions it aims to answer are:
Does absolute hemoglobin decline during the first 24 hours of admission independently predict prolonged intensive care unit stay in critically ill adult patients?
Does absolute hemoglobin decline during the first 24 hours of admission independently predict in-hospital mortality in critically ill adult patients?
Participants will:
Have their routine clinical and laboratory data reviewed retrospectively from their electronic health records (including baseline hemoglobin and a second hemoglobin determination approximately 24 hours after admission). No additional interventions or extra blood draws will be performed beyond routine clinical care.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients (aged 18 years or older) admitted to the Intensive Care Unit (ICU) between January 2024 and January
- •ICU length of stay greater than 48 hours.
- •At least two hemoglobin determinations obtained with an interval of approximately 24 hours apart during routine medical care.
排除标准
- •Massive bleeding upon ICU admission.
- •Massive transfusion protocol activation.
- •Pregnancy.
- •Hemoglobinopathies.
- •Active hemolytic anemia.
- •Medical records with insufficient information for analysis.
研究组 & 干预措施
Critically Ill Adult Patients
Adult patients admitted to the intensive care unit with an ICU stay of more than 48 hours and at least two hemoglobin determinations obtained approximately 24 hours apart during routine care.
干预措施: Early Absolute Hemoglobin Decline (Other)
结局指标
主要结局
Prolonged Intensive Care Unit Stay
时间窗: From ICU admission up to 28 days
Incidence of prolonged intensive care unit (ICU) length of stay, defined a priori as an ICU stay equal to or greater than 8 days.
次要结局
- In-Hospital Mortality(From ICU admission up to 30 days)
研究者
Jose J Zaragoza, MD MSc
Principal Investigator
Hospital H+ Queretaro