Ultrasound-guided Continous Quadratus Lumborum Block: Effect on Acute Pain and Quality of Recovery After Hepatic Surgery With Right Subcostal Incision
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Cumulative morphine consumption
研究概览
简要总结
This prospective, randomized study, control study aims to compare the analgesic effect, opioids consumption, quality of recovery, length of hospital stay and et al. between unilateral continuous quadratus lumborum block (QLB) and intravenous patient-controlled analgesia (IPCA) alone in patients undergoing hepatectomy with right J-shape subcostal incision.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 18-70 yrs
- •American Society of Anesthesiologists physical statusⅠ-Ⅲ
- •Undergo hepatectomy with right J-shape subcostal incision
- •Informed consent
排除标准
- •A known allergy to the drugs being used
- •Coagulopathy, on anticoagulants
- •Analgesics intake, history of substance abuse
- •Participating in the investigation of another experimental agent
- •Inability to properly describe postoperative pain to investigators (eg, language barrier, neuropsychiatric disorder)
研究组 & 干预措施
Continuous QLB+postoperative IPCA
Single-injection of QLB (quadratus lumborum block) is given preoperatively followed with continuous infusion+ postoperative IPCA (intravenous patient control analgesia)
干预措施: Continous QLB (quadratus lumborum block) (Procedure)
Continuous QLB+postoperative IPCA
Single-injection of QLB (quadratus lumborum block) is given preoperatively followed with continuous infusion+ postoperative IPCA (intravenous patient control analgesia)
干预措施: Philip CX50 Ultrasound Scanner (Device)
Continuous QLB+postoperative IPCA
Single-injection of QLB (quadratus lumborum block) is given preoperatively followed with continuous infusion+ postoperative IPCA (intravenous patient control analgesia)
干预措施: Ropivacaine (Drug)
Continuous QLB+postoperative IPCA
Single-injection of QLB (quadratus lumborum block) is given preoperatively followed with continuous infusion+ postoperative IPCA (intravenous patient control analgesia)
干预措施: Morphine given as IPCA (Drug)
IPCA
Postoperative IPCA (intravenous patient control analgesia) is given alone
干预措施: Morphine given as IPCA (Drug)
结局指标
主要结局
Cumulative morphine consumption
时间窗: at 24 postoperative hours
次要结局
- Time of recovery of bowl movement(within the 7 days after surgery)
- Quality of recovery(3 days and 7 days after surgery)
- Nausea and Vomiting score(At 0, 2,4, 8, 12, 24 and 48 hours after the surgery)
- Ambulation time(within the 7 days after surgery)
- Patient satisfaction with anesthesia(48 hours after surgery)
- Postoperative hospital length of stay(Up to 6 weeks)
- Pruritus score(At 0, 2,4, 8, 12, 24 and 48 hours after the surgery)
- The pain scores determined by the numeric rating scale (NRS, 0-10)(At 0, 2,4, 8, 12, 24 ,48,72 hours and 7 day after the surgery)
研究者
Cui Xulei
Attending Physician
Peking Union Medical College Hospital