Role of cerebral blood flow pulsatility in hypertension related brain damage

Maastricht University Medical Center0 个研究点目标入组 75 人开始时间: 待定最近更新: 2024年6月11日

试验速览

暂无简介。

•Criteria for the hypertensive group without known brain damage:
•- Age 40-75 years
•- Essential hypertension, defined as an ambulant blood pressure of = 130 over 80 mmHg.
•Criteria for the hypertensive group with diagnosed brain damage (Fazekas=2):
•- Age 40-75 years
•- Essential hypertension, defined as an ambulant blood pressure of = 130 over 80 mmHg.
•- Extensive white matter lesions: Fazekas score = 2, indicated on brain MRI.
•Criteria for the control (normotensive) group:
•- Age 40-75 years
•- Normotensive (ambulant blood pressure of < 130 over 80 mmHg).

•- White coat hypertension
•- Inability to stop antihypertensive medication (since this results in an altered blood pressure, not the original blood pressure before the use of medication.)
•- Indication of history-taking, physical examination or routine laboratory tests of secondary hypertension
•- Chronic renal insufficiency (eGFR<30 mL/min)
•- Diabetes mellitus
•- Ischemic or valvular heart disease or electrocardiographic evidence of atrial fibrillation
•- Transient ischemic attacks and ischemic or hemorrhagic stroke
•- Obstructive sleep apnea syndrome
•- Systemic inflammation, such as active rheumatoid arthritis
•- Body Mass Index > 32 kg/m²
•- Inability to provide informed consent
•- Any contraindication for MRI: metallic implants, pacemaker, claustrophobia, pregnancy, tattoos in the head/neck region, permanent make-up.
•- Contraindications for the gadolinium-containing contrast agent: allergic reaction, eGFR<30 mL/min

发起方