Changes of the Neuronal Activity in the Subthalamic Nucleus Under Remifentanil Sedation During Stereotactic Electrode Implantation
试验速览
- 阶段
- 不适用
- 入组人数
- 20
- 主要终点
- Electrical activity in the basal ganglia
研究概览
简要总结
Deep brain stimulation is commonly used for the treatment of movement disorders. Electrode positioning is usually performed under local anesthesia in fully awake patients. The procedure is uncomfortable to the patients who has to remain motionless during the whole surgery. Previous reports of electrode positioning under general anesthesia was found to be less accurate. This result was probably due to the effect of the anesthetics on the electrical activity of the basal ganglia.
The purpose of this study is to detect possible changes in the electrical activity of the basal ganglia related to remifentanil sedation. electrical activity of single neurons will be recorded before, during and after sedation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with movement disorder, who are candidates for implantation of deep brain stimulation electrode.
排除标准
- •Suspected difficult intubation
- •history of sleep apnea
- •known allergy for remifentanil
研究组 & 干预措施
A
The patients get a period of sedation with remifentanil, before, during and after which, the changes in the electrical activity of the Basal Ganglia is recorded.
干预措施: Remifentanil (Drug)
结局指标
主要结局
Electrical activity in the basal ganglia
时间窗: During the experiment
次要结局
未报告次要终点