NCT01573481已完成不适用
Pressure Controlled Ventilation Versus Pressure Support Ventilation During the Night: New Strategy of Mechanical Ventilation Weaning?
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 19
- 试验地点
- 2
- 主要终点
- Weaning duration
研究概览
简要总结
The purpose of the study is to compare pressure controlled continuous mandatory ventilation versus pressure support ventilation during the night for weaning to mechanical ventilation in chronic obstructive pulmonary disease patients and their impact onto sleep quality.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •The patient and/or legal representative of the patient has provided a written informed consent before inclusion in the study
- •The patients is hospitalized in respiratory and critical care unit (university hospital of AMIENS, FRANCE)
- •the patient is mechanically ventilated (ventilator model : puritan-bennett B840)
- •Pulmonary disease,chronic obstructive (Spirometry and Blood Gas Analysis in chronic state before admission)
- •stable cardiovascular status (cardiac frequency < 140 beats/min and systolic blood pressure : 90-160 mmHg without catecholamines)
- •midazolam < 0,05mg/kg/h
- •sufentanyl < 0,05µ/kg/h
- •the disorder that caused respiratory failure and prompted mechanical ventilation is treated
- •the clinician suspects the patient may be ready to begin the weaning process
- •inspiratory oxygen fraction (FiO2) < 50%
- •positive end-expiratory pressure < or equal 8cmH2O
- •during the day, the patient tolerate pressure support ventilation (pressure support level < 15cmH2O
- •respiratory frequency (FR) < 35 breaths/min
- •tidal volume (VT) > 5ml/kg
- •PaO2/FiO2 > 200 mmHg
- •FR/VT < 105 breaths/min/L
排除标准
- •sleep apnea, central
- •narcolepsy
- •Encephalopathy, Metabolic AND Encephalitis
结局指标
主要结局
Weaning duration
时间窗: between one to 21 days (the study will begin when patient presents weaning criteria and will stop 48 days after extubation.)
weaning duration in days (from the first day with spontaneous ventilation to extubation)
次要结局
- weaning failure(48 hours)
- Quantity and quality of sleep(1 to 21 days)
研究者
研究点 (2)
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