Improving Cognitive Functions by Training Distractor Inhibition (DIIN) in Younger and Older Healthy Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- Improvements in test performance
研究概览
简要总结
The investigators are interested in how attentional filter training/ distractor inhibition training could influence cognitive functions like working memory, executive control, problem solving, decision making and attentional control.
详细描述
Two different computer based trainings were applied: an attentional filter training and a working memory training.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •right-hander
- •aged between 18-30 or 60-80years
排除标准
- •severe visual impairments (e.g. dyschromatopsia, very low vision)
- •diseases or medication that might impair test performance
- •Montreal Cognitive Assessment Score (MoCA) < 26 points
研究组 & 干预措施
Young subjects
Working memory training & attentional filter training for participants (18-30 years)
干预措施: filter training (Behavioral)
Young subjects
Working memory training & attentional filter training for participants (18-30 years)
干预措施: memory training (Behavioral)
Old subjects
Working memory training, attentional filter training and no training (control) for participants (60-80 years)
干预措施: filter training (Behavioral)
Old subjects
Working memory training, attentional filter training and no training (control) for participants (60-80 years)
干预措施: memory training (Behavioral)
Old subjects
Working memory training, attentional filter training and no training (control) for participants (60-80 years)
干预措施: no training (control) (Other)
结局指标
主要结局
Improvements in test performance
时间窗: 45min pre / post
Working memory and filtering performance (in %), effects of distractor interference and reaction times for trials with and without distractors with 4, 5 \& 6 targets
次要结局
- Memory from TAP (Test battery of Attentional Performance)(45min pre / post)
- Attention from TAP (Test battery of Attentional Performance)(45min pre / post)
- Performance in repeating numbers(10min pre / post)
- Rey Complex Figure Test(30min pre / post)
- Subtest from CANTAB (Cambridge Neuropsychological Test Automated Battery)(10min pre / post)
- Iowa Gambling Task(5min on each training day (1-5))
- Daily Questionnaires(2min on each training day (1-5))
- Memory performance with distractors among different setsizes(45min pre / post)
- Filtering performance with distractors among different setsizes(45min pre / post)
- Memory performance without distractors among different setsizes(45min pre / post)
- Filtering performance without distractors among different setsizes(45min pre / post)
- Reaction times(45min pre / post)
- Values of distractor inhibition(45min pre / post)
研究者
Notger Müller
Prof. Dr. med. (Head of Neuroprotection Lab at the DZNE)
German Center for Neurodegenerative Diseases (DZNE)