Efficacy Evaluation of Microwave Ablation Assisted by Diaphragm Hydrodissection for Hepatocellular Carcinoma and Comparative Analysis With Surgical
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 200
- 主要终点
- Progression-free survival (PFS)
研究概览
简要总结
The goal of this observational study is to evaluate the local efficacy and safety of hydrodissection-assisted microwave ablation for patients with hepatocellular carcinoma, and to compare its therapeutic outcomes with surgical resection for hepatocellular carcinoma. The main questions it aims to answer are:
Is hydrodissection-assisted microwave ablation safe and effective for treating hepatocellular carcinoma? How does the therapeutic effect of hydrodissection-assisted microwave ablation compare with surgical resection for hepatocellular carcinoma? Patients who receive either microwave ablation or surgical resection will Undergo a 2-year follow-up period.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with Child-Pugh grade A or B liver function.Single hepatic lesion with a maximum diameter ≤ 5 cm.The lesion is located in the subphrenic region with a distance ≤ 10 mm from the right diaphragm.
排除标准
- •Presence of extrahepatic metastasis or other concomitant malignant tumors.Presence of severe cardiac, pulmonary, or renal dysfunction.Platelet count < 50×10⁹/L with irreversible coagulation disorders. Patients with incomplete imaging or clinical medical data.
研究组 & 干预措施
Hydrodissection-assisted microwave ablation cohort
Patients with hepatocellular carcinoma receiving hydrodissection-assisted microwave ablation under routine clinical care. No study-specific intervention will be assigned by researchers.
干预措施: Microwave Ablation Assisted by Diaphragm Hydrodissection (Procedure)
Surgical resection cohort
Patients with hepatocellular carcinoma receiving surgical resection under routine clinical care. No study-specific intervention will be assigned by researchers.
干预措施: Surgical Resection (Procedure)
结局指标
主要结局
Progression-free survival (PFS)
时间窗: Up to 2 years after treatment
the time from initiation of treatment to disease progression or death.
次要结局
- Overall survival (OS)(Up to 2 years after treatment)
研究者
Dezhi Zhang
Associate Chief Physician，Abdominal Ultrasound Department
The First Hospital of Jilin University