The central mechanism of acupuncture for the patients with knee osteoarthritis: study protocol for a randomized controlled trial

The First Affiliated Hospital of Henan University of CM0 个研究点开始时间: 待定最近更新: 2023年2月20日

适应症

试验速览

暂无简介。

•1. Male or female, aged 45–75 years;
•2. Following the diagnostic criteria of knee osteoarthritis, and Right-handed;
•3. Good compliance and willing to cooperate with the research;
•4. Radiologic confirmation of knee osteoarthritis (Kellgren–Lawrence grade I-III);
•5. The informed consent form was signed by the patient or by their immediate family members.

•1. Complicated with other knee joint diseases, such as tuberculosis, tumor, rheumatism and rheumatoid arthritis; 2. Complicated with sprain, contusion or other trauma, foot deformity, pain and other diseases affecting normal walking;
•3. Patients with severe cardiovascular disease, damage of liver and kidney function, immune deficiency, diabetes mellitus, and blood disease;
•4. Severe drug and alcohol dependence, mania or schizophrenia;
•5. Patients with obvious headache, migraine, dysmenorrhea and other chronic pain diseases, history of head trauma;
•6. Be insensitive to pain due to advanced diabetes, neuropathy or use of strong painkillers;
•7. have knee pain caused by radiculopathy/herniation of an intervertebral disc;
•8. Have a history of prolotherapy, hyaluronic acid injections or corticosteroids injections within 3 months;
•9. have received acupuncture, electro-acupuncture, Tui-na therapy, massage, or physiotherapy 8 weeks prior to enrolment in the trial;
•10. Have MRI contraindications such as claustrophobia, cardiac pacemaker, defibrillator, heart stenting, or intrauterine device.

发起方