Pulse EnRiched Food and Exercise Clinical Trials (PERFECT Project): Part 1 - Acute Effects of Pulse Ingredients in Snack Products on Appetite, Blood Glucose, and Food Intake in Adults - Study 1
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Food Intake
研究概览
简要总结
The objectives are to test the acute effects of different extruded pulse snacks on: 1) post-prandial blood glucose, insulin and appetite for two hours, and 2) food intake two hours following consumption of pulse products.
The investigators hypothesize that snack products containing pulse ingredients will lead to lower blood glucose, insulin, appetite and food intake responses compared to non-pulse snack products.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Normoglycemic (<5.6 mmol/L) and normotensive (systolic blood pressure <140 mm Hg and diastolic blood pressure below < 90 mm Hg)
- •BMI of 18.5-29.9 kg/m2
排除标准
- •Restrained eaters
- •Regularly skip breakfast
- •Those on medications that may influence study outcomes or have experienced any gastrointestinal related health conditions/surgeries over the past year
- •Competitive sports or athletic training at a high intensity
- •Those unable to walk for an hour continuously
研究组 & 干预措施
Extruded snack with pinto bean flour
60% corn flour and 40% pinto bean flour
干预措施: Pinto bean flour (Other)
Extruded snack control
100% corn flour
干预措施: Control (Other)
Extruded snack with small particle size pea flour
60% corn flour and 40% small particle size pea flour
干预措施: Small particle size pea flour (Other)
Extruded snack with large particle size pea flour
60% corn flour and 40% large particle size pea flour
干预措施: Large particle size pea flour (Other)
Extruded snack with lentil flour
60% corn flour and 40% lentil flour
干预措施: Lentil flour (Other)
Extruded snack navy bean flour
60% corn flour and 40% navy bean flour
干预措施: Navy bean flour (Other)
结局指标
主要结局
Food Intake
时间窗: at 120 min
Ad-libitum meal
Subjective Appetite
时间窗: 0-200 min
Measured by VAS questionnaire at 12 time points used to calculate area under curve (AUC) (Composite measure)
Plasma Glucose and Insulin Concentrations
时间窗: 0 - 200 min
Measured in blood using intravenous catheter at 12 time points and used to calculate area under curve (AUC). Glucose will be determined by automated methods using Abbot Spectrum CCX Analyzer, and Insulin will be measured by commercially available RIA kits (Composite measure)
次要结局
- Physical Comfort(0-200 min)
- Palatability of meal(at 140 minutes)
- Palatability of treatments(at 5 minutes)
- Energy and Fatigue(0-200 min)