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临床试验/NCT00818467
NCT00818467已完成4 期

3% Dihydroxyacetone (DHA or Sunless Tanning Agent) Inhibits Vitamin D Production in the Skin in Response to Ultraviolet Light

Creighton University2 个研究点 分布在 1 个国家目标入组 50 人开始时间: 2008年5月最近更新:
适应症

试验速览

阶段
4 期
状态
已完成
入组人数
50
试验地点
2
主要终点
To measure the response of 25(OH)D to 40 milliJoules of UV-B light in white Caucasians with melanoidins-sunscreen from 3% DHA in comparison to the response of control subjects who have not used 3% DHA.

研究概览

简要总结

Patients need vitamin D which is normally produced in the skin in response to ultraviolet light from the sun. Vitamin D is important for calcium absorption and good bone health. Physicians have been using sunscreens to protect patients from skin cancer and the aging effects of sunlight for a least a half a century. Dermatologists have promoted sunscreen use to restrict sunlight exposure especially in white Caucasians. If this behavior is done 100% of the time when outdoors individuals may suffer from vitamin D deficiency. It is impossible to influence persons' behavior to wear sunscreens all the time when outdoors. With the use of sunless tanning agent (DHA), once a week, we can obtain a continuous sunscreen in the top layer of the skin that will not wash off, can't be removed with soap and water, or removed by perspiration. Under these circumstances we can answer the scientific question, will sunscreen use inhibit the production of vitamin D in the skin?

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
None

入排标准

年龄范围
19 Years 至 50 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • males or females
  • ages 19-50 with less than 16 oz milk per day
  • less than 10 hours of sun per week
  • no Vitamin D supplements
  • no anticonvulsants
  • no barbiturates
  • no steroids
  • no meds that increase photosensitivity
  • no granulomatous disease
  • no liver or kidney disease
  • no history of skin cancer
  • BMI less than 30
  • skin types I & II

排除标准

  • 未提供

结局指标

主要结局

To measure the response of 25(OH)D to 40 milliJoules of UV-B light in white Caucasians with melanoidins-sunscreen from 3% DHA in comparison to the response of control subjects who have not used 3% DHA.

时间窗: 1 month

次要结局

未报告次要终点

研究者

申办方类型
Other

研究点 (2)

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