NCT05779514招募中不适用
Effect of Mirabegron on Promoting Brown Adipose Tissue Activation
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- The growth of brown adipose tissue by PET-CT
研究概览
简要总结
In previous preclinical studies, our group found that Mirabegron, a clinical drug, could activate brown adipose tissue and inhibit tumor growth in tumour-bearing mice.Investigators look forward to further evaluating the effect of Mirabegron-mediated brown adipose tissue activation, so as to provide new drug applications for clinical cancer prevention and treatment
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Health Volunteers
- •Sign the informed consent before the study, and fully understand the content, process and possible adverse events.
- •Both men and women, aged 18-75 years (including the boundary value) .
- •Body mass index (BMI) is 19.0-26.0 kg/m2 (including the boundary value).
- •Tumor patients
- •Sign the informed consent before the study, and fully understand the content, process and possible adverse events.
- •Tumor bearing and not in the period of chemotherapy and targeted drug intervention).
- •Both men and women, aged 18-75 years (including the boundary value) .
- •Body mass index (BMI) is 19.0-26.0 kg/m2 (including the boundary value).
- •Proper bone marrow and organ function, as defined below:HB≥80h/L; ANC≥1.5*109/L; PLT≥50*109/L; ALT≤3 upper limit of normal ( ULN ); AST≤3 ULN ; TBIL≤1.5 ULN.
- •The expected survival is 3 months or more.
排除标准
- •Health Volunteers and Tumor patients
- •A history of tuberculosis infection.
- •Patients with contraindications to Mirabegron: allergic to Mirabegron or any of its excipients; Patients with poorly controlled severe hypertension(SBP≧180mmHg or/and DBP≧110mmHg).
- •Women who are pregnant or breastfeeding.
- •The subject may not be able to complete the study for other reasons or may not be able to participate in the study for other reasons judged by the investigator.
研究组 & 干预措施
The growth of brown adipose tissue
Experimental
干预措施: Mirabegron (Drug)
结局指标
主要结局
The growth of brown adipose tissue by PET-CT
时间窗: Day 0 and Day 28
Growth of brown adipose tissue after 28 days of oral administration of Mirabegron was measured by standard uptake value (SUV) values measured by PET-CT .
次要结局
- blood glucose and glucose tolerance test ( GTT ) by Hematological tests(Day 0 and Day 28)
研究者
研究点 (1)
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