Effects of oxygen status on Hypoxia Inducible Factor 1-a. A pilot proof of principle study. - Oxygen status and Hypoxia Inducible Factor 1-a

niversitair Medisch Centrum Sint Radboud0 个研究点目标入组 20 人开始时间: 待定最近更新: 2024年4月29日

适应症

试验速览

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•-Use of any medication, smoking
•-History, signs or symptoms of cardiovascular disease, history of atrial or ventricular arrhythmia, (Family) history of myocardial infarction or stroke under the age of 65 years, cardiac conduction abnormalities on the ECG consisting of a 2nd degree atrioventricular block or a complex bundle branch block, hypertension (defined as RR systolic > 160 or RR diastolic > 90), hypotension (defined as RR systolic < 100 or RR diastolic < 50)
•-Renal impairment (defined as plasma creatinine >120 µmol/l), Liver enzyme abnormalities alkaline phosphatase>230 U/L and/or ALT>90 U/L
•-Medical history of any obvious disease associated with immune deficiency, pre-existent lung disease or asthma
•-CRP > 20 mg/L, WBC > 12x109/L, or clinically significant acute illness, including infections, within 4 weeks before endotoxemia day
•-Participation in a drug trial or donation of blood 3 months prior to the experiment, use of recreational drugs within 21 days prior to experiment day, visit to altitude >1500m within 4 weeks prior to the experiment, air travel with flight time over 3 hours within 4 weeks prior to the experiment, history of acute mountain sickness, recent hospital admission or surgery with general anaesthesia (<3 months)
•-Claustrophobia
•-Feelings of discomfort during a 10 minute test wearing the transparent respiratory helmet at the screening visit

发起方

niversitair Medisch Centrum Sint Radboud